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The Journal of Neuroscience, December 12, 2007, 27(50):13756-13761; doi:10.1523/JNEUROSCI.4053-07.2007

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Brief Communications
Semilunar Granule Cells: Glutamatergic Neurons in the Rat Dentate Gyrus with Axon Collaterals in the Inner Molecular Layer

Philip A. Williams, Phillip Larimer, Yuan Gao, and Ben W. Strowbridge

Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106

Correspondence should be addressed to Dr. Ben W. Strowbridge, Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106. Email: bens{at}case.edu

Synaptic reorganization of the dentate gyrus inner molecular layer (IML) is a pathophysiological process that may facilitate seizures in patients with temporal-lobe epilepsy. Two subtypes of IML neurons were originally described by Ramón y Cajal (1995), but have not been thoroughly studied. We used two-photon imaging, infrared-differential interference contrast microscopy and patch clamp recordings from rat hippocampal slices to define the intrinsic physiology and synaptic targets of spiny, granule-like neurons in the IML, termed semilunar granule cells (SGCs). These neurons resembled dentate granule cells but had axon collaterals in the molecular layer, significantly larger dendritic arborization in the molecular layer, and a more triangular cell body than granule cells. Unlike granule cells, SGCs fired throughout long-duration depolarizing steps and had ramp-like depolarizations during interspike periods. Paired recordings demonstrated that SGCs are glutamatergic and monosynaptically excite both hilar interneurons and mossy cells. Semilunar granule cells appear to represent a distinct excitatory neuron population in the dentate gyrus that may be an important target for mossy fiber sprouting in patients and rodent models of temporal lobe epilepsy.

Key words: hippocampus; two-photon imaging; EPSP; dentate gyrus; dentate hilus; mossy cell; epilepsy

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Received Sept. 5, 2007; revised Oct. 23, 2007; accepted Nov. 9, 2007.

Correspondence should be addressed to Dr. Ben W. Strowbridge, Department of Neurosciences, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106. Email: bens{at}case.edu

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