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The Journal of Neuroscience, December 12, 2007, 27(50):13854-13865; doi:10.1523/JNEUROSCI.4494-07.2007

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Development/Plasticity/Repair
β1 Integrins in Radial Glia But Not in Migrating Neurons Are Essential for the Formation of Cell Layers in the Cerebral Cortex

Richard Belvindrah,1 Diana Graus-Porta,2 Sandra Goebbels,3 Klaus-Armin Nave,3 and Ulrich Müller1

1Department of Cell Biology, Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, 2Novartis Pharma Services, Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland, and 3Department of Neurogenetics, Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany

Correspondence should be addressed to Ulrich Müller, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92073. Email: umueller{at}scripps.edu

Radial glial cells in the cerebral cortex serve as progenitors for neurons and glia and guide the migration of cortical neurons. The integrin {alpha}3β1 is thought to mediate interactions of migrating neurons with radial glial cells and to function as a receptor for the reelin signaling molecule. Here, we challenge this view and demonstrate that β1 integrins in migrating neurons are not essential for the formation of cell layers in the cerebral cortex. Cortical cell layers also form normally in mice deficient in the integrin {alpha}3β1. However, we provide evidence that β1 integrins in radial glia control the morphological differentiation of both glia and neurons. We conclude that β1 integrins in radial glia are required for the proper development of the cerebral cortex, whereas β1 integrins in migrating neurons are not essential for glial-guided migration and reelin signaling.

Key words: integrin; cell migration; radial glia; cerebral cortex; nervous system; reelin

Received July 14, 2006; accepted Oct. 25, 2007.

Correspondence should be addressed to Ulrich Müller, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92073. Email: umueller{at}scripps.edu


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