 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, February 7, 2007, 27(6):1285-1296; doi:10.1523/JNEUROSCI.4873-06.2007
Previous Article | Next Article
Cellular/Molecular
The Spatial Organization of Long-Term Synaptic Plasticity at the Input Stage of Cerebellum
Jonathan Mapelli andEgidio D'Angelo Department of Cellular and Molecular Physiological and Pharmacological Sciences, University of Pavia and National Institute for the Physics of Matter, I-27100 Pavia, Italy
Correspondence should be addressed to Egidio D'Angelo, Department of Cellular and Molecular Physiological and Pharmacological Sciences, University of Pavia and National Institute for the Physics of Matter, Via Forlanini 6, I-27100 Pavia, Italy. Email: dangelo{at}unipv.it
The spatial organization of long-term synaptic plasticity [long-term potentiation (LTP) and long-term depression (LTD)] is supposed to play a critical role for distributed signal processing in neuronal networks, but its nature remains undetermined in most central circuits. By using multielectrode array recordings, we have reconstructed activation maps of the granular layer in cerebellar slices. LTP and LTD induced by theta-burst stimulation appeared in patches organized in such a way that, on average, LTP was surrounded by LTD. The sign of long-term synaptic plasticity in a given granular layer region was directly correlated with excitation and inversely correlated with inhibition: the most active areas tended to generate LTP, whereas the least active areas tended to generate LTD. Plasticity was almost entirely prevented by application of the NMDA receptor blocker, APV. This suggests that synaptic inhibition, through a control of membrane depolarization, effectively regulates NMDA channel unblock, postsynaptic calcium entry, and the induction of bidirectional synaptic plasticity at the mossy fiber–granule cell relay (Gall et al., 2005). By this mechanism, LTP and LTD could regulate the geometry and contrast of network computations, preprocessing the mossy fiber input to be conveyed to Purkinje cells and molecular layer interneurons.
Key words: LTP; LTD; synaptic inhibition; cerebellum; granular layer; multielectrode array; signal propagation
Received July 6, 2006; revised Dec. 9, 2006; accepted Dec. 23, 2006.
Correspondence should be addressed to Egidio D'Angelo, Department of Cellular and Molecular Physiological and Pharmacological Sciences, University of Pavia and National Institute for the Physics of Matter, Via Forlanini 6, I-27100 Pavia, Italy. Email: dangelo{at}unipv.it
This article has been cited by other articles:
L. Mapelli, P. Rossi, T. Nieus, and E. D'Angelo
Tonic Activation of GABAB Receptors Reduces Release Probability at Inhibitory Connections in the Cerebellar Glomerulus
J Neurophysiol, June 1, 2009; 101(6): 3089 - 3099.
[Abstract] [Full Text] [PDF]
S. Diwakar, J. Magistretti, M. Goldfarb, G. Naldi, and E. D'Angelo
Axonal Na+ Channels Ensure Fast Spike Activation and Back-Propagation in Cerebellar Granule Cells
J Neurophysiol, February 1, 2009; 101(2): 519 - 532.
[Abstract] [Full Text] [PDF]
F. Prestori, P. Rossi, B. Bearzatto, J. Laine, D. Necchi, S. Diwakar, S. N. Schiffmann, H. Axelrad, and E. D'Angelo
Altered Neuron Excitability and Synaptic Plasticity in the Cerebellar Granular Layer of Juvenile Prion Protein Knock-Out Mice with Impaired Motor Control
J. Neurosci., July 9, 2008; 28(28): 7091 - 7103.
[Abstract] [Full Text] [PDF]
L. Roggeri, B. Rivieccio, P. Rossi, and E. D'Angelo
Tactile Stimulation Evokes Long-Term Synaptic Plasticity in the Granular Layer of Cerebellum
J. Neurosci., June 18, 2008; 28(25): 6354 - 6359.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|