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The Journal of Neuroscience, February 7, 2007, 27(6):1479-1484; doi:10.1523/JNEUROSCI.3711-06.2007

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Neurobiology of Disease
The Neural Code of Auditory Phantom Perception

Nathan Weisz,^1,2 Simona Müller,¹ Winfried Schlee,¹ Katalin Dohrmann,¹ Thomas Hartmann,¹ and Thomas Elbert¹

¹Department of Psychology, University of Konstanz, D-78464 Konstanz, Germany, and ² Institut National de la Santé et de la Recherche Médicale, Unité 280, 69500 Lyon, France

Correspondence should be addressed to Nathan Weisz at his present address, Institut National de la Santé et de la Recherche Médicale, Unité 280, Centre Hospitalier Le Vinatier, Bâtiment 452 95 Boulevard Pinel, 69500 Bron, France. Email: weisz{at}lyon.inserm.fr

Tinnitus is defined by an auditory perception in the absence of an external source of sound. This condition provides the distinctive possibility of extracting neural coding of perceptual representation. Previously, we had established that tinnitus is characterized by enhanced magnetic slow-wave activity (4 Hz) in perisylvian or putatively auditory regions. Because of works linking high-frequency oscillations to conscious sensory perception and positive symptoms in a variety of disorders, we examined gamma band activity during brief periods of marked enhancement of slow-wave activity. These periods were extracted from 5 min of resting spontaneous magnetoencephalography activity in 26 tinnitus and 21 control subjects. Results revealed the following, particularly within a frequency range of 50–60 Hz: (1) Both groups showed significant increases in gamma band activity after onset of slow waves. (2) Gamma is more prominent in tinnitus subjects than in controls. (3) Activity at 55 Hz determines the laterality of the tinnitus perception.

Based on present and previous results, we have concluded that cochlear damage, or similar types of deafferentation from peripheral input, triggers reorganization in the central auditory system. This produces permanent alterations in the ongoing oscillatory dynamics at the higher layers of the auditory hierarchical stream. The change results in enhanced slow-wave activity reflecting altered corticothalamic and corticolimbic interplay. Such enhancement facilitates and sustains gamma activity as a neural code of phantom perception, in this case auditory.

Key words: tinnitus; phantom perception; gamma band activity; slow-wave activity; magnetoencephalography; spontaneous activity

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Received Aug. 25, 2006; revised Dec. 6, 2006; accepted Dec. 7, 2006.

Correspondence should be addressed to Nathan Weisz at his present address, Institut National de la Santé et de la Recherche Médicale, Unité 280, Centre Hospitalier Le Vinatier, Bâtiment 452 95 Boulevard Pinel, 69500 Bron, France. Email: weisz{at}lyon.inserm.fr

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