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The Journal of Neuroscience, February 21, 2007, 27(8):1942-1953; doi:10.1523/JNEUROSCI.3208-06.2007

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Cellular/Molecular
Kv4.3-Mediated A-Type K⁺ Currents Underlie Rhythmic Activity in Hippocampal Interneurons

Mathieu L. Bourdeau, ^* France Morin, ^* Charles E. Laurent, Mounia Azzi,  and Jean-Claude Lacaille

Département de Physiologie, Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montréal, Québec, Canada H3C 3J7

Correspondence should be addressed to Dr. Jean-Claude Lacaille, Département de Physiologie, Université de Montréal, Cas Postal 6128 Succursale Centre-ville, Montréal, Québec, Canada H3C 3J7. Email: jean-claude.lacaille{at}umontreal.ca

Hippocampal-dependent learning and memory processes are associated with theta frequency rhythmic activity. Interneuron and pyramidal cell network interactions underlie this activity, but contributions of interneuron voltage-gated membrane conductances remain unclear. We show that interneurons at the CA1 lacunosum-moleculare (LM) and radiatum (RAD) junction (LM/RAD) display voltage-dependent subthreshold membrane potential oscillations (MPOs) generated by voltage-gated tetrodotoxin-sensitive Na⁺ and 4-aminopyridine (4-AP)-sensitive K⁺ currents. They also exhibit prominent 4-AP-sensitive A-type K⁺ currents, with gating properties showing activation at subthreshold membrane potentials. We found that LM/RAD cells are part of specific interneuron subpopulations expressing the K⁺ channel subunit Kv4.3 and their transfection with Kv4.3 small interfering RNA selectively impaired A-type K⁺ currents and MPOs. Thus, our findings reveal a novel function of Kv4.3-mediated A-type K⁺ currents in the generation of intrinsic MPOs in specific subpopulations of interneurons that may participate in hippocampal theta-related rhythmic activity.

Key words: theta rhythm; CA1 hippocampus; inhibitory interneurons; slice cultures; membrane potential oscillations; K⁺ channels

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Received July 26, 2006; revised Jan. 15, 2007; accepted Jan. 15, 2007.

Correspondence should be addressed to Dr. Jean-Claude Lacaille, Département de Physiologie, Université de Montréal, Cas Postal 6128 Succursale Centre-ville, Montréal, Québec, Canada H3C 3J7. Email: jean-claude.lacaille{at}umontreal.ca

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