 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
The Journal of Neuroscience, February 28, 2007, 27(9):2349-2356; doi:10.1523/JNEUROSCI.5587-06.2007
Previous Article | Next Article
Behavioral/Systems/Cognitive
Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control
William W. Seeley,1 Vinod Menon,2,3 Alan F. Schatzberg,2 Jennifer Keller,2 Gary H. Glover,3,4 Heather Kenna,2 Allan L. Reiss,2,3 andMichael D. Greicius2,5 1Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, and 2Department of Psychiatry, 3Program in Neuroscience, 4Department of Radiology, and 5Department of Neurology, Stanford University School of Medicine, Stanford, California 94305
Correspondence should be addressed to Michael D. Greicius, Departments of Neurology and Neurological Sciences and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 300 Pasteur Drive, Room A343, Stanford, CA 94305-5235. Email: greicius{at}stanford.edu
Variations in neural circuitry, inherited or acquired, may underlie important individual differences in thought, feeling, and action patterns. Here, we used task-free connectivity analyses to isolate and characterize two distinct networks typically coactivated during functional MRI tasks. We identified a "salience network," anchored by dorsal anterior cingulate (dACC) and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an "executive-control network" that links dorsolateral frontal and parietal neocortices. These intrinsic connectivity networks showed dissociable correlations with functions measured outside the scanner. Prescan anxiety ratings correlated with intrinsic functional connectivity of the dACC node of the salience network, but with no region in the executive-control network, whereas executive task performance correlated with lateral parietal nodes of the executive-control network, but with no region in the salience network. Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior.
Key words: fMRI; functional connectivity; anterior cingulate; insula; salience; anxiety
Received Sept. 28, 2006; revised Jan. 19, 2007; accepted Jan. 22, 2007.
Correspondence should be addressed to Michael D. Greicius, Departments of Neurology and Neurological Sciences and Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 300 Pasteur Drive, Room A343, Stanford, CA 94305-5235. Email: greicius{at}stanford.edu
This article has been cited by other articles:
S. S. Wu, T. T. Chang, A. Majid, S. Caspers, S. B. Eickhoff, and V. Menon
Functional Heterogeneity of Inferior Parietal Cortex during Mathematical Cognition Assessed with Cytoarchitectonic Probability Maps
Cereb Cortex, December 1, 2009; 19(12): 2930 - 2945.
[Abstract] [Full Text] [PDF]
D. S. Margulies, J. L. Vincent, C. Kelly, G. Lohmann, L. Q. Uddin, B. B. Biswal, A. Villringer, F. X. Castellanos, M. P. Milham, and M. Petrides
Precuneus shares intrinsic functional architecture in humans and monkeys
PNAS, November 24, 2009; 106(47): 20069 - 20074.
[Abstract] [Full Text] [PDF]
A. R. Laird, S. B. Eickhoff, K. Li, D. A. Robin, D. C. Glahn, and P. T. Fox
Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling
J. Neurosci., November 18, 2009; 29(46): 14496 - 14505.
[Abstract] [Full Text] [PDF]
S. Sadaghiani, G. Hesselmann, and A. Kleinschmidt
Distributed and Antagonistic Contributions of Ongoing Activity Fluctuations to Auditory Stimulus Detection
J. Neurosci., October 21, 2009; 29(42): 13410 - 13417.
[Abstract] [Full Text] [PDF]
C. M. Lewis, A. Baldassarre, G. Committeri, G. L. Romani, and M. Corbetta
From the Cover: Learning sculpts the spontaneous activity of the resting human brain
PNAS, October 13, 2009; 106(41): 17558 - 17563.
[Abstract] [Full Text] [PDF]
Z. Shehzad, A. M. C. Kelly, P. T. Reiss, D. G. Gee, K. Gotimer, L. Q. Uddin, S. H. Lee, D. S. Margulies, A. K. Roy, B. B. Biswal, et al.
The Resting Brain: Unconstrained yet Reliable
Cereb Cortex, October 1, 2009; 19(10): 2209 - 2229.
[Abstract] [Full Text] [PDF]
A. D. Craig
Disembodied hallucinatory voices: Comment on Sommer et al., 2008 Brain 131, 3169-77
Brain, October 1, 2009; 132(10): e123 - e123.
[Full Text] [PDF]
C. L. Grady, A. B. Protzner, N. Kovacevic, S. C. Strother, B. Afshin-Pour, M. Wojtowicz, J. A. E. Anderson, N. Churchill, and A. R. McIntosh
A Multivariate Analysis of Age-Related Differences in Default Mode and Task-Positive Networks across Multiple Cognitive Domains
Cereb Cortex, September 29, 2009; (2009) bhp207v1.
[Abstract] [Full Text] [PDF]
S.W.H. Wong, L. Jong, D. Bandur, F. Bihari, Y. -F. Yen, A. M. Takahashi, D. H. Lee, D. A. Steven, A. G. Parrent, S. E. Pigott, et al.
Cortical reorganization following anterior temporal lobectomy in patients with temporal lobe epilepsy
Neurology, August 18, 2009; 73(7): 518 - 525.
[Abstract] [Full Text] [PDF]
C. Habas, N. Kamdar, D. Nguyen, K. Prater, C. F. Beckmann, V. Menon, and M. D. Greicius
Distinct Cerebellar Contributions to Intrinsic Connectivity Networks
J. Neurosci., July 1, 2009; 29(26): 8586 - 8594.
[Abstract] [Full Text] [PDF]
M. D. Fox, D. Zhang, A. Z. Snyder, and M. E. Raichle
The Global Signal and Observed Anticorrelated Resting State Brain Networks
J Neurophysiol, June 1, 2009; 101(6): 3270 - 3283.
[Abstract] [Full Text] [PDF]
P. Gatev and T. Wichmann
Interactions between Cortical Rhythms and Spiking Activity of Single Basal Ganglia Neurons in the Normal and Parkinsonian State
Cereb Cortex, June 1, 2009; 19(6): 1330 - 1344.
[Abstract] [Full Text] [PDF]
M. H. Immordino-Yang, A. McColl, H. Damasio, and A. Damasio
From the Cover: Neural correlates of admiration and compassion
PNAS, May 12, 2009; 106(19): 8021 - 8026.
[Abstract] [Full Text] [PDF]
W.-J. Kuo, T. Sjostrom, Y.-P. Chen, Y.-H. Wang, and C.-Y. Huang
Intuition and Deliberation: Two Systems for Strategizing in the Brain
Science, April 24, 2009; 324(5926): 519 - 522.
[Abstract] [Full Text] [PDF]
M. J. Hoptman, D. D'Angelo, D. Catalano, C. J. Mauro, Z. E. Shehzad, A. M. C. Kelly, F. X. Castellanos, D. C. Javitt, and M. P. Milham
Amygdalofrontal Functional Disconnectivity and Aggression in Schizophrenia
Schizophr Bull, April 16, 2009; (2009) sbp012v2.
[Abstract] [Full Text] [PDF]
G. L. Shulman, S. V. Astafiev, D. Franke, D. L. W. Pope, A. Z. Snyder, M. P. McAvoy, and M. Corbetta
Interaction of Stimulus-Driven Reorienting and Expectation in Ventral and Dorsal Frontoparietal and Basal Ganglia-Cortical Networks
J. Neurosci., April 8, 2009; 29(14): 4392 - 4407.
[Abstract] [Full Text] [PDF]
A.M. C. Kelly, A. Di Martino, L. Q. Uddin, Z. Shehzad, D. G. Gee, P. T. Reiss, D. S. Margulies, F. X. Castellanos, and M. P. Milham
Development of Anterior Cingulate Functional Connectivity from Late Childhood to Early Adulthood
Cereb Cortex, March 1, 2009; 19(3): 640 - 657.
[Abstract] [Full Text] [PDF]
C. Nioche, E.A. Cabanis, and C. Habas
Functional Connectivity of the Human Red Nucleus in the Brain Resting State at 3T
AJNR Am. J. Neuroradiol., February 1, 2009; 30(2): 396 - 403.
[Abstract] [Full Text] [PDF]
M. D. Greicius, K. Supekar, V. Menon, and R. F. Dougherty
Resting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network
Cereb Cortex, January 1, 2009; 19(1): 72 - 78.
[Abstract] [Full Text] [PDF]
J. A. Church, D. A. Fair, N. U. F. Dosenbach, A. L. Cohen, F. M. Miezin, S. E. Petersen, and B. L. Schlaggar
Control networks in paediatric Tourette syndrome show immature and anomalous patterns of functional connectivity
Brain, January 1, 2009; 132(1): 225 - 238.
[Abstract] [Full Text] [PDF]
J. L. Vincent, I. Kahn, A. Z. Snyder, M. E. Raichle, and R. L. Buckner
Evidence for a Frontoparietal Control System Revealed by Intrinsic Functional Connectivity
J Neurophysiol, December 1, 2008; 100(6): 3328 - 3342.
[Abstract] [Full Text] [PDF]
R. C. Welsh, A. C. Chen, and S. F. Taylor
Low-Frequency BOLD Fluctuations Demonstrate Altered Thalamocortical Connectivity in Schizophrenia
Schizophr Bull, November 5, 2008; (2008) sbn145v1.
[Abstract] [Full Text] [PDF]
I. A. Strigo, A. N. Simmons, S. C. Matthews, A. D. Craig, and M. P. Paulus
Association of Major Depressive Disorder With Altered Functional Brain Response During Anticipation and Processing of Heat Pain
Arch Gen Psychiatry, November 1, 2008; 65(11): 1275 - 1284.
[Abstract] [Full Text] [PDF]
B. J. He, A. Z. Snyder, J. M. Zempel, M. D. Smyth, and M. E. Raichle
From the Cover: Electrophysiological correlates of the brain's intrinsic large-scale functional architecture
PNAS, October 14, 2008; 105(41): 16039 - 16044.
[Abstract] [Full Text] [PDF]
D. Zhang, A. Z. Snyder, M. D. Fox, M. W. Sansbury, J. S. Shimony, and M. E. Raichle
Intrinsic Functional Relations Between Human Cerebral Cortex and Thalamus
J Neurophysiol, October 1, 2008; 100(4): 1740 - 1748.
[Abstract] [Full Text] [PDF]
C. Habas and E.A. Cabanis
Dissociation of the Neural Networks Recruited during a Haptic Object-Recognition Task: Complementary Results with a Tensorial Independent Component Analysis
AJNR Am. J. Neuroradiol., October 1, 2008; 29(9): 1715 - 1721.
[Abstract] [Full Text] [PDF]
D. Sridharan, D. J. Levitin, and V. Menon
A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks
PNAS, August 26, 2008; 105(34): 12569 - 12574.
[Abstract] [Full Text] [PDF]
D. A. Fair, A. L. Cohen, N. U. F. Dosenbach, J. A. Church, F. M. Miezin, D. M. Barch, M. E. Raichle, S. E. Petersen, and B. L. Schlaggar
The maturing architecture of the brain's default network
PNAS, March 11, 2008; 105(10): 4028 - 4032.
[Abstract] [Full Text] [PDF]
W. W. Seeley, R. Crawford, K. Rascovsky, J. H. Kramer, M. Weiner, B. L. Miller, and M. L. Gorno-Tempini
Frontal Paralimbic Network Atrophy in Very Mild Behavioral Variant Frontotemporal Dementia
Arch Neurol, February 1, 2008; 65(2): 249 - 255.
[Abstract] [Full Text] [PDF]
P. J. Gianaros, L. K. Sheu, K. A. Matthews, J. R. Jennings, S. B. Manuck, and A. R. Hariri
Individual Differences in Stressor-Evoked Blood Pressure Reactivity Vary with Activation, Volume, and Functional Connectivity of the Amygdala
J. Neurosci., January 23, 2008; 28(4): 990 - 999.
[Abstract] [Full Text] [PDF]
G.D. Rabinovici, W.W. Seeley, E.J. Kim, M.L. Gorno-Tempini, K. Rascovsky, T.A. Pagliaro, S.C. Allison, C. Halabi, J.H. Kramer, J.K. Johnson, et al.
Distinct MRI Atrophy Patterns in Autopsy-Proven Alzheimer's Disease and Frontotemporal Lobar Degeneration
American Journal of Alzheimer's Disease and Other Dementias, January 1, 2008; 22(6): 474 - 488.
[Abstract] [PDF]
W. W. Seeley, B. R. Matthews, R. K. Crawford, M. L. Gorno-Tempini, D. Foti, I. R. Mackenzie, and B. L. Miller
Unravelling Bolero: progressive aphasia, transmodal creativity and the right posterior neocortex
Brain, January 1, 2008; 131(1): 39 - 49.
[Abstract] [Full Text] [PDF]
P. Fransson, B. Skiold, S. Horsch, A. Nordell, M. Blennow, H. Lagercrantz, and U. Aden
Resting-state networks in the infant brain
PNAS, September 25, 2007; 104(39): 15531 - 15536.
[Abstract] [Full Text] [PDF]
D. A. Fair, N. U. F. Dosenbach, J. A. Church, A. L. Cohen, S. Brahmbhatt, F. M. Miezin, D. M. Barch, M. E. Raichle, S. E. Petersen, and B. L. Schlaggar
Development of distinct control networks through segregation and integration
PNAS, August 14, 2007; 104(33): 13507 - 13512.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|