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The Journal of Neuroscience, April 9, 2008, 28(15):3911-3919; doi:10.1523/JNEUROSCI.0148-08.2008

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Development/Plasticity/Repair
Impaired Adult Neurogenesis Associated with Short-Term Memory Defects in NF-B p50-Deficient Mice

Suzanne Denis-Donini,^1,2 * Anna Dellarole,^3,4 * Paola Crociara,^3,4 Maria Teresa Francese,^3,4 Valeria Bortolotto,^3,4 Giorgia Quadrato,^3,4 Pier Luigi Canonico,^3,4 Marco Orsetti,^3,4 Piera Ghi,⁵ Maurizio Memo,⁶ Sara Anna Bonini,⁶ Giulia Ferrari-Toninelli,⁶ and Mariagrazia Grilli^3,4

¹Department of Biology, Section of Zoology and Cytology, University of Milan and ²Neuroscience Institute, National Research Council, Milan 20100, Italy, ³Department of Chemical, Food, Pharmaceutical, and Pharmacological Sciences (DiSCAFF), University of Piemonte Orientale "A. Avogadro" and ⁴Drug and Food Biotechnology Center, Novara 28100, Italy, ⁵Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin 10125, Italy, and ⁶Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia 25100, Italy

Correspondence should be addressed to Prof. Mariagrazia Grilli, Laboratory of Neuroplasticity and Pain, Department of Chemical, Food, Pharmaceutical, and Pharmacological Sciences (DiSCAFF) and Drug and Food Biotechnology Center, Via Bovio 6, 28100 Novara, Italy. Email: grilli{at}pharm.unipmn.it

Neurogenesis proceeds throughout adulthood in the brain of most mammalian species, but the molecular mechanisms underlying the regulation of stem/progenitor cell proliferation, survival, maturation, and differentiation have not been completely unraveled. We have studied hippocampal neurogenesis in NF-B p50-deficient mice. Here we demonstrate that in absence of p50, the net rate of neural precursor proliferation does not change, but some of the steps leading to the final neuron differentiation status are hampered, resulting in 50% reduction in the number of newly born neurons in the adult mutant hippocampus. Additionally, in p50^–/– mice, we observed a selective defect in short-term spatial memory performance without impairment of hippocampal-dependent spatial long-term memory and learning. Our results highlight the role of NF-B p50 in hippocampal neurogenesis and in short-term spatial memory.

Key words: NF-B; neurogenesis; hippocampus; memory; calretinin; doublecortin

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Received Jan. 13, 2008; revised Feb. 20, 2008; accepted March 5, 2008.

Correspondence should be addressed to Prof. Mariagrazia Grilli, Laboratory of Neuroplasticity and Pain, Department of Chemical, Food, Pharmaceutical, and Pharmacological Sciences (DiSCAFF) and Drug and Food Biotechnology Center, Via Bovio 6, 28100 Novara, Italy. Email: grilli{at}pharm.unipmn.it

This article has been cited by other articles:

				B. Kaltschmidt and C. Kaltschmidt NF-{kappa}B in the Nervous System Cold Spring Harb Perspect Biol, September 1, 2009; 1(3): a001271 - a001271. [Abstract] [Full Text] [PDF]

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