WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, May 21, 2008, 28(21):5513-5518; doi:10.1523/JNEUROSCI.5374-07.2008

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gais, S.
Right arrow Articles by Born, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gais, S.
Right arrow Articles by Born, J.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Visual–Procedural Memory Consolidation during Sleep Blocked by Glutamatergic Receptor Antagonists

Steffen Gais, Björn Rasch, Ullrich Wagner, and Jan Born

Department of Neuroendocrinology, University of Lübeck, 23538 Lübeck, Germany

Correspondence should be addressed to either Jan Born or Steffen Gais, Department of Neuroendocrinology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Email: born{at}kfg.uni-luebeck.de or Email: gais{at}kfg.uni-luebeck.de

Visual cortex plasticity is enhanced by sleep. It is hypothesized that a reactivation of glutamatergic synapses is essential for this form of plasticity to occur after learning. To test this hypothesis, human subjects practiced a visual texture discrimination skill known to require post-training sleep for improvements to occur. During sleep, glutamatergic transmission was inhibited by administration of the two glutamate antagonists, caroverine and ketamine, targeting the ionotropic NMDA and AMPA receptors. Both substances given during consolidation sleep in a placebo controlled crossover design were able to prevent improvement of the skill measured the next morning. An off-line activation of glutamatergic synapses therefore seems to play a critical part in the consolidation of plastic changes in the visual cortex.

Key words: sleep; memory consolidation; skill learning; visual discrimination; glutamate receptor; human

Received Dec. 5, 2007; revised March 11, 2008; accepted April 4, 2008.

Correspondence should be addressed to either Jan Born or Steffen Gais, Department of Neuroendocrinology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Email: born{at}kfg.uni-luebeck.de or Email: gais{at}kfg.uni-luebeck.de






 -
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-