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The Journal of Neuroscience, May 28, 2008, 28(22):5654-5659; doi:10.1523/JNEUROSCI.0756-08.2008

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Brief Communications
Organization of the Arp2/3 Complex in Hippocampal Spines

Bence Rácz1 and Richard J. Weinberg2

1Department of Anatomy and Histology, Faculty of Veterinary Science, Szent István University, 1078 Budapest, Hungary, and 2Department of Cell and Developmental Biology, and Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599-7090

Correspondence should be addressed to Bence Rácz, Szent Istvan University, István u. 2, 1078 Budapest, Hungary. Email: racz.bence{at}aotk.szie.hu

Changes in the morphology of a dendritic spine require remodeling of its actin-based cytoskeleton. Biochemical mechanisms underlying actin remodeling have been studied extensively, but little is known about the physical organization of the actin-binding proteins that mediate remodeling in spines. Long-term potentiation-inducing stimuli trigger expansion of the spine head, suggesting local extension and branching of actin filaments. Because filament branching requires the Arp2/3 complex, we used quantitative immunoelectron microscopy to elucidate the organization of ARPC-2 (Arp2/3 complex subunit 2), an essential component of the complex. Our data from CA1 hippocampus indicate that Arp2/3 concentrates within spines in a previously unrecognized torroidal domain, apparently specialized to mediate actin filament branching.

Key words: actin; cytoskeleton; hippocampus; LTP; pyramidal cell; synaptic plasticity

Received Feb. 19, 2008; revised April 17, 2008; accepted April 20, 2008.

Correspondence should be addressed to Bence Rácz, Szent Istvan University, István u. 2, 1078 Budapest, Hungary. Email: racz.bence{at}aotk.szie.hu


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