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The Journal of Neuroscience, June 11, 2008, 28(24):6104-6110; doi:10.1523/JNEUROSCI.0437-08.2008

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Brief Communications
Cell Type-Specific Firing during Ripple Oscillations in the Hippocampal Formation of Humans

Michel Le Van Quyen,^1,2 Anatol Bragin,³ Richard Staba,³ Benoit Crépon,^1,2 Charles L. Wilson,³ and Jerome Engel, Jr³

¹Centre National de la Recherche Scientifique, Cognitive Neuroscience and Brain Imaging Laboratory, Unité Propre de Recherche 640, Hôpital de la Pitié-Salpêtrière, 75651 Paris, France, ²Université Pierre et Marie Curie-Paris 6, 75005 Paris, France, and ³Neurology Department, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095

Correspondence should be addressed to either of the following: Michel Le Van Quyen, Centre National de la Recherche Scientifique, Cognitive Neuroscience and Brain Imaging Laboratory, Unité Propre de Recherche 640, Hôpital de la Pitié-Salpêtrière, 47 Boulevard de l'Hôpital, 75651 Paris cedex 13, France, Email: lenalm{at}ext.jussieu.fr; or Anatol Bragin, Neurology Department, David Geffen School of Medicine at University of California, Los Angeles, 710, Westwood Plaza, Los Angeles, CA 90095, Email: ABragin{at}mednet.ucla.edu

High-frequency field ripples occur in the rodent hippocampal formation and are assumed to depend on interneuron type-specific firing patterns, structuring the activity of pyramidal cells. Ripples with similar characteristics are also present in humans, yet their underlying cellular correlates are still unknown. By in vivo recording interneurons and pyramidal cells in the human hippocampal formation, we find that cell type-specific firing patterns and phase-locking on a millisecond timescale can be distinguished during ripples. In particular, pyramidal cells fired preferentially at the highest amplitude of the ripple, but interneurons began to discharge earlier than pyramidal cells. Furthermore, a large fraction of cells were phase-locked to the ripple cycle, but the preferred phase of discharge of interneurons followed the maximum discharge probability of pyramidal neurons. These relationships between human ripples and unit activity are qualitatively similar to that observed in vivo in the rodents, suggesting that their underlying mechanisms are similar.

Key words: ripple; sharp wave; oscillation; interneuron; human hippocampus; EEG

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Received Jan. 31, 2008; revised March 26, 2008; accepted April 6, 2008.

Correspondence should be addressed to either of the following: Michel Le Van Quyen, Centre National de la Recherche Scientifique, Cognitive Neuroscience and Brain Imaging Laboratory, Unité Propre de Recherche 640, Hôpital de la Pitié-Salpêtrière, 47 Boulevard de l'Hôpital, 75651 Paris cedex 13, France, Email: lenalm{at}ext.jussieu.fr; or Anatol Bragin, Neurology Department, David Geffen School of Medicine at University of California, Los Angeles, 710, Westwood Plaza, Los Angeles, CA 90095, Email: ABragin{at}mednet.ucla.edu

This article has been cited by other articles:

				W. C. Stacey, M. T. Lazarewicz, and B. Litt Synaptic Noise and Physiological Coupling Generate High-Frequency Oscillations in a Hippocampal Computational Model J Neurophysiol, October 1, 2009; 102(4): 2342 - 2357. [Abstract] [Full Text] [PDF]

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