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The Journal of Neuroscience, June 18, 2008, 28(25):6402-6406; doi:10.1523/JNEUROSCI.1204-08.2008

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Brief Communications
GluR6/KA2 Kainate Receptors Mediate Slow-Deactivating Currents

Andrea Barberis, Shankar Sachidhanandam, and Christophe Mulle

Laboratoire Physiologie Cellulaire de la Synapse, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5091, Bordeaux Neuroscience Institute, University of Bordeaux 2, 33077 Bordeaux, France

Correspondence should be addressed to either Andrea Barberis or Christophe Mulle at the above address. Email: andrea.barberis{at}iit.it or Email: mulle{at}u-bordeaux2.fr

Kainate receptors (KARs) are ionotropic glutamate receptors contributing to EPSCs with a slow-decaying component that is likely essential for synaptic integration. The slow kinetics of KAR-EPSCs markedly contrasts with the fast kinetics reported for recombinant KARs expressed in heterologous systems, for reasons that remain unexplained. Here we have studied the properties of recombinant heteromeric GluR6/KA2 receptors, which compose synaptic KARs. We report that, in response to brief glutamate applications, currents mediated by recombinant GluR6/KA2 receptors, but not GluR6 receptors, decay with a time course similar to KAR-EPSCs. Model simulations suggest that, after brief agonist exposures, GluR6/KA2 currents undergo slow deactivation caused by the stabilization of partially bound open states. We propose, therefore, that the GluR6/KA2 gating features could contribute to the slow KAR-EPSC decay kinetics.

Key words: kainate receptor; KAR-EPSC kinetics; gating properties; desensitization; glutamate receptor; synaptic transmission

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Received March 20, 2008; revised May 5, 2008; accepted May 5, 2008.

Correspondence should be addressed to either Andrea Barberis or Christophe Mulle at the above address. Email: andrea.barberis{at}iit.it or Email: mulle{at}u-bordeaux2.fr

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