WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, July 9, 2008, 28(28):7036-7039; doi:10.1523/JNEUROSCI.0834-08.2008

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Strange, B. A.
Right arrow Articles by Dolan, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Strange, B. A.
Right arrow Articles by Dolan, R. J.

 Previous Article  |  Next Article 

Brief Communications
Emotion-Induced Retrograde Amnesia Is Determined by a 5-HTT Genetic Polymorphism

Bryan A. Strange, Marijn C. W. Kroes, Jonathan P. Roiser, Geoffrey C. Y. Tan, and Raymond J. Dolan

Wellcome Trust Centre for Neuroimaging, Institute of Neurology, London WC1N 3BG, United Kingdom

Correspondence should be addressed to Bryan A. Strange, Wellcome Trust Centre for Neuroimaging, 12 Queen Square, London WC1N 3BG, UK. Email: bstrange{at}fil.ion.ucl.ac.uk

A polymorphism in the human serotonin transporter (5-HTT) gene is implicated in susceptibility to anxiety and depression and in enhanced emotion-induced activation in the amygdala. A role for 5-HTT polymorphism in the emotional modulation of human episodic memory has yet to be demonstrated. Here, we demonstrate that whereas emotional memory for aversive events per se is not influenced by 5-HTT polymorphism, an emotion-induced retrograde amnesia is expressed solely in the presence of the short allele. The findings indicate a critical role for the serotonin system in emotion-mediated memory disruption.

Key words: serotonin (5-HT); 5-HTT; polymorphism; emotion; memory; retrograde amnesia

Received Feb. 25, 2008; revised April 29, 2008; accepted May 22, 2008.

Correspondence should be addressed to Bryan A. Strange, Wellcome Trust Centre for Neuroimaging, 12 Queen Square, London WC1N 3BG, UK. Email: bstrange{at}fil.ion.ucl.ac.uk




This article has been cited by other articles:


Home page
 Soc Cogn Affect NeurosciHome page
L. G. Crisan, S. Pana, R. Vulturar, R. M. Heilman, R. Szekely, B. Druga, N. Dragos, and A. C. Miu
Genetic contributions of the serotonin transporter to social learning of fear and economic decision making
Soc Cogn Affect Neurosci, December 1, 2009; 4(4): 399 - 408.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2010 by Society for Neuroscience ONLINE ISSN: 1529-2401
-