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The Journal of Neuroscience, July 9, 2008, 28(28):7068-7073; doi:10.1523/JNEUROSCI.0771-08.2008

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Brief Communications
P₀ Protein Is Required for and Can Induce Formation of Schmidt-Lantermann Incisures in Myelin Internodes

Xinghua Yin,¹ Grahame J. Kidd,¹ Klaus-Amin Nave,² and Bruce D. Trapp¹

¹Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, and ²Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany

Correspondence should be addressed to Dr. Bruce D. Trapp, Department of Neurosciences, NC30, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195. Email: trappb{at}ccf.org

Axons in the PNS and CNS are ensheathed by multiple layers of tightly compacted myelin membranes. A series of cytoplasmic channels connect outer and inner margins of PNS, but not CNS, myelin internodes. Membranes of these Schmidt-Lantermann (S-L) incisures contain the myelin-associated glycoprotein (MAG) but not P₀ or proteolipid protein (PLP), the structural proteins of compact PNS (P₀) and CNS (PLP) myelin. We show here that incisures are present in MAG-null and absent from P₀-null PNS internodes. To test the possibility that P₀ regulates incisure formation, we replaced PLP with P₀ in CNS myelin. S-L incisures formed in P₀-CNS myelin internodes. Furthermore, axoplasm ensheathed by 65% of the CNS incisures examined by electron microscopy had focal accumulations of organelles, indicating that these CNS incisures disrupt axonal transport. These data support the hypotheses that P₀ protein is required for and can induce S-L incisures and that P₀-induced CNS incisures can be detrimental to axonal function.

Key words: myelin; P₀ protein; proteolipid protein; myelin-associated glycoprotein; axon; axonal transport

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Received Feb. 20, 2008; revised May 22, 2008; accepted May 27, 2008.

Correspondence should be addressed to Dr. Bruce D. Trapp, Department of Neurosciences, NC30, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195. Email: trappb{at}ccf.org

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Roles of myelin protein species

Heikki Savolainen

J. Neurosci. Online, 22 Jul 2008 [Full text]

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