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The Journal of Neuroscience, January 16, 2008, 28(3):696-710; doi:10.1523/JNEUROSCI.4931-07.2008

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Behavioral/Systems/Cognitive
Intrinsic Mechanisms for Adaptive Gain Rescaling in Barrel Cortex

Marta Díaz-Quesada and Miguel Maravall

Instituto de Neurociencias de Alicante, Universidad Miguel Hernández de Elche-Consejo Superior de Investigaciones Científicas, Campus de San Juan, 03550 Sant Joan d'Alacant, Spain

Correspondence should be addressed to Miguel Maravall, Instituto de Neurociencias de Alicante, Universidad Miguel Hernández de Elche-Consejo Superior de Investigaciones Científicas, Campus de San Juan, Apartado 18, 03550 Sant Joan d'Alacant, Spain. Email: mmaravall{at}umh.es

Barrel cortex neuronal responses adapt to changes in the statistics of complex whisker stimuli. This form of adaptation involves an adjustment in the input–output tuning functions of the neurons, such that their gain rescales depending on the range of the current stimulus distribution. Similar phenomena have been observed in other sensory systems, suggesting that adaptive adjustment of responses to ongoing stimulus statistics is an important principle of sensory function. In other systems, adaptation and gain rescaling can depend on intrinsic properties; however, in barrel cortex, whether intrinsic mechanisms can contribute to adaptation to stimulus statistics is unknown. To examine this, we performed whole-cell patch-clamp recordings of pyramidal cells in acute slices while injecting stochastic current stimuli. We induced changes in statistical context by switching across stimulus distributions. The firing rates of neurons adapted in response to changes in stimulus statistics. Adaptation depended on the form of the changes in stimulus distribution: in vivo-like adaptation occurred only for rectified stimuli that maintained neurons in a persistent state of net depolarization. Under these conditions, neurons rescaled the gain of their input–output functions according to the scale of the stimulus distribution, as observed in vivo. This stimulus-specific adaptation was caused by intrinsic properties and correlated strongly with the amplitude of calcium-dependent slow afterhyperpolarizations. Our results suggest that widely expressed intrinsic mechanisms participate in barrel cortex adaptation but that their recruitment is highly stimulus specific.

Key words: vibrissa; somatosensory; noise; sensory coding; slice; afterhyperpolarization; gain control

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Received July 11, 2007; accepted Nov. 29, 2007.

Correspondence should be addressed to Miguel Maravall, Instituto de Neurociencias de Alicante, Universidad Miguel Hernández de Elche-Consejo Superior de Investigaciones Científicas, Campus de San Juan, Apartado 18, 03550 Sant Joan d'Alacant, Spain. Email: mmaravall{at}umh.es

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