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The Journal of Neuroscience, July 30, 2008, 28(31):7883-7890; doi:10.1523/JNEUROSCI.1265-08.2008

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Behavioral/Systems/Cognitive
Sequence Reactivation in the Hippocampus Is Impaired in Aged Rats

Jason L. Gerrard,2 Sara N. Burke,1,2 Bruce L. McNaughton,1,2,3,5 and Carol A. Barnes1,2,3,4

1Evelyn F. McKnight Brain Institute, 2Arizona Research Laboratories Division of Neural Systems, Memory and Aging, and Departments of 3Psychology, 4Neurology, and 5Physiology, University of Arizona, Tucson, Arizona 85724

Correspondence should be addressed to Dr. Carol A. Barnes, Life Sciences North Building, Room 384, The Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ 85724. Email: carol{at}nsma.arizona.edu

The hippocampus is thought to coordinate memory consolidation by reactivating traces from behavioral experience when the brain is not actively processing new input. In fact, during slow-wave sleep, the patterns of CA1 pyramidal cell ensemble activity correlations are reactivated in both young and aged rats. In addition to correlated activity patterns, repetitive track running also creates a recurring sequence of pyramidal cell activity. The present study compared CA1 sequence activity pattern replay in young and old animals during rest periods after behavior. Whereas the young rats exhibited significant sequence reactivation, it was markedly impaired in the aged animals. When the spatial memory scores of all animals were compared with the degree of sequence reactivation, there was a significant correlation. The novel finding that weak replay of temporal patterns has behavioral consequences, strengthens the idea that reactivation processes are integral to memory consolidation.

Key words: aging; attractor dynamics; CA1; memory consolidation; place field; neural ensemble

Received March 24, 2008; revised May 8, 2008; accepted May 21, 2008.

Correspondence should be addressed to Dr. Carol A. Barnes, Life Sciences North Building, Room 384, The Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ 85724. Email: carol{at}nsma.arizona.edu




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