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The Journal of Neuroscience, August 20, 2008, 28(34):8397-8405; doi:10.1523/JNEUROSCI.0630-08.2008

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Behavioral/Systems/Cognitive
Gamma-Band Activity in Human Posterior Parietal Cortex Encodes the Motor Goal during Delayed Prosaccades and Antisaccades

Jurrian Van Der Werf,^1,2 Ole Jensen,² Pascal Fries,^2,3 and W. Pieter Medendorp^1,2

¹Nijmegen Institute for Cognition and Information, ²F. C. Donders Centre for Cognitive Neuroimaging, and ³Department of Biophysics, Radboud University Nijmegen, NL-6500 HE Nijmegen, The Netherlands

Correspondence should be addressed to Jurrian Van Der Werf, Nijmegen Institute for Cognition and Information, Radboud University Nijmegen, P.O. Box 9104, NL-6500 HE Nijmegen, The Netherlands. Email: j.vanderwerf{at}nici.ru.nl

Although it is well established that parietal cortex is important in processing sensorimotor transformations, less is known about the neuronal dynamics of this process in humans. Using magnetoencephalography, we investigated the dynamics of parietal oscillatory activity during saccade planning in terms of sensory and motor goal processing. In the experiments, a peripheral stimulus was flashed in either the left or right hemifield, followed by a 1.5 s delay period, after which the subject executed a saccade toward (prosaccade) or away from (antisaccade) the stimulus. In response to stimulus presentation, we observed an initial increase in gamma-band power (40–120 Hz) in a region in the posterior parietal cortex contralateral to the direction of the stimulus. This lateralized power enhancement, which was sustained in a more narrow frequency band (85–105 Hz) during the delay period of prosaccades, mapped to the hemisphere contralateral to the direction of the saccade goal during the delay period of antisaccades. These results suggest that neuronal gamma-band synchronization in parietal cortex represents the planned direction of the saccade, not the memorized stimulus location. In the lower-frequency bands, we observed sustained contralateral alpha (7–13 Hz) power suppression after stimulus presentation in parieto-occipital regions. The dynamics of the alpha band was strongly related to the processing of the stimulus and showed only modest selectivity for the goal of the saccade. We conclude that parietal gamma-band synchronization reflects a mechanism to encode the motor goals in the visuomotor processing for saccades.

Key words: human; MEG; oscillations; parietal cortex; saccade; sensorimotor; spatial updating

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Received Feb. 12, 2008; revised June 13, 2008; accepted July 3, 2008.

Correspondence should be addressed to Jurrian Van Der Werf, Nijmegen Institute for Cognition and Information, Radboud University Nijmegen, P.O. Box 9104, NL-6500 HE Nijmegen, The Netherlands. Email: j.vanderwerf{at}nici.ru.nl

Related articles in J. Neurosci.:

Role of Posterior Parietal Gamma Activity in Planning Prosaccades and Antisaccades

Karim Jerbi, Carlos M. Hamamé, Tomás Ossandón, and Sarang S. Dalal
J. Neurosci. 2008 28: 13713-13715. [Full Text]  

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				K. Jerbi, C. M. Hamame, T. Ossandon, and S. S. Dalal Role of Posterior Parietal Gamma Activity in Planning Prosaccades and Antisaccades J. Neurosci., December 17, 2008; 28(51): 13713 - 13715. [Full Text] [PDF]

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