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The Journal of Neuroscience, August 20, 2008, 28(34):8635-8643; doi:10.1523/JNEUROSCI.1411-08.2008

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Cellular/Molecular
Downregulation of Dendritic I_h in CA1 Pyramidal Neurons after LTP

Emilie Campanac,^1,2 Gaël Daoudal,^1,2 Norbert Ankri,^1,2 and Dominique Debanne^1,2

¹Inserm U641 and ²Faculté de Médecine Nord, Université de la Méditerranée, 13916 Marseille, France

Correspondence should be addressed to Dominique Debanne at the above address. Email: dominique.debanne{at}univmed.fr

Hyperpolarization-activated (h)-channels occupy a central position in dendritic function. Although it has been demonstrated that these channels are upregulated after large depolarizations to reduce dendritic excitation, it is not clear whether they also support other forms of long-term plasticity. We show here that nearly maximal long-term potentiation (LTP) induced by theta-burst pairing produced upregulation in h-channel activity in CA1 pyramidal neurons. In contrast, moderate LTP induced by spike-timing-dependent plasticity or high-frequency stimulation (HFS) downregulated the h-current (I_h) in the dendrites. After HFS-induced LTP, the h-conductance (G_h) was reduced without changing its activation. Pharmacological blockade of I_h had no effect on LTP induction, but occluded EPSP-to-spike potentiation, an input-specific facilitation of dendritic integration. Dynamic-clamp reduction of G_h locally in the dendrite mimicked the effects of HFS and enhanced synaptic integration in an input-selective way. We conclude that dendritic I_h is locally downregulated after induction of nonmaximal LTP, thus facilitating integration of the potentiated input.

Key words: EPSP–spike plasticity; homeostatic plasticity; dendrite; dendritic integration; dynamic clamp; Hebbian

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Received April 3, 2008; revised July 7, 2008; accepted July 21, 2008.

Correspondence should be addressed to Dominique Debanne at the above address. Email: dominique.debanne{at}univmed.fr

This article has been cited by other articles:

				J.-D. Breton and G. J. Stuart Loss of sensory input increases the intrinsic excitability of layer 5 pyramidal neurons in rat barrel cortex J. Physiol., November 1, 2009; 587(21): 5107 - 5119. [Abstract] [Full Text] [PDF]

				D. Debanne Plasticity of neuronal excitability in vivo J. Physiol., July 1, 2009; 587(13): 3057 - 3058. [Full Text] [PDF]

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