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The Journal of Neuroscience, September 3, 2008, 28(36):8934-8944; doi:10.1523/JNEUROSCI.4030-07.2008

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Behavioral/Systems/Cognitive
Receptive Field Shift and Shrinkage in Macaque Middle Temporal Area through Attentional Gain Modulation

Thilo Womelsdorf,^1,2 Katharina Anton-Erxleben,² and Stefan Treue^2,3

¹F.C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands, ²Cognitive Neuroscience Laboratory, German Primate Center, 37077 Göttingen, Germany, and ³Department of Biology, Göttingen University, 37077 Göttingen, Germany

Correspondence should be addressed to Thilo Womelsdorf, F.C. Donders Centre for Cognitive Neuroimaging, Radboud University, Kapittelweg 29, 6525 EN Nijmegen, The Netherlands. Email: t.womelsdorf{at}fcdonders.ru.nl

Selective attention is the top-down mechanism to allocate neuronal processing resources to the most relevant subset of the information provided by an organism's sensors. Attentional selection of a spatial location modulates the spatial-tuning characteristics (i.e., the receptive fields of neurons in macaque visual cortex). These tuning changes include a shift of receptive field centers toward the focus of attention and a narrowing of the receptive field when the attentional focus is directed into the receptive field. Here, we report that when attention is directed into versus of receptive fields of neurons in the middle temporal visual area (area MT), the magnitude of the shift of the spatial-tuning functions is positively correlated with a narrowing of spatial tuning around the attentional focus. By developing and applying a general attentional gain model, we show that these nonmultiplicative attentional modulations of basic neuronal-tuning characteristics could be a direct consequence of a spatially distributed multiplicative interaction of a bell-shaped attentional spotlight with the spatially fined-grained sensory inputs of MT neurons. Additionally, the model lets us estimate the spatial spread of the attentional top-down signal impinging on visual cortex. Consistent with psychophysical reports, the estimated size of the "spotlight of attention" indicates a coarse spatial resolution of attention. These results illustrate how spatially specific nonmultiplicative attentional changes of neuronal-tuning functions can be the result of multiplicative gain modulation affecting sensory neurons in a widely distributed region in cortical space.

Key words: attention; receptive field; gain modulation; visual motion; area MT; tuning

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Received April 15, 2007; revised June 17, 2008; accepted July 14, 2008.

Correspondence should be addressed to Thilo Womelsdorf, F.C. Donders Centre for Cognitive Neuroimaging, Radboud University, Kapittelweg 29, 6525 EN Nijmegen, The Netherlands. Email: t.womelsdorf{at}fcdonders.ru.nl

This article has been cited by other articles:

				K. Anton-Erxleben, V. M. Stephan, and S. Treue Attention Reshapes Center-Surround Receptive Field Structure in Macaque Cortical Area MT Cereb Cortex, October 1, 2009; 19(10): 2466 - 2478. [Abstract] [Full Text] [PDF]

				M. Scolari and J. T. Serences Adaptive Allocation of Attentional Gain J. Neurosci., September 23, 2009; 29(38): 11933 - 11942. [Abstract] [Full Text] [PDF]

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