QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, September 24, 2008, 28(39):9828-9839; doi:10.1523/JNEUROSCI.2328-08.2008

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Rehm, K. J. Articles by Marder, E. Search for Related Content PubMed PubMed Citation Articles by Rehm, K. J. Articles by Marder, E.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Developmental Regulation of Neuromodulator Function in the Stomatogastric Ganglion of the Lobster, Homarus americanus

Kristina J. Rehm, Katherine E. Deeg, and Eve Marder

Volen Center, Brandeis University, Waltham, Massachusetts 02454-9110

Correspondence should be addressed to Kristina J. Rehm at her present address: Dana Farber Cancer Institute, 44 Binney Street, Dana 620, Boston, MA 02115. Email: Kristina_Rehm{at}DFCI.Harvard.edu

Neuromodulatory substances have profound effects on the two motor patterns generated by the adult crustacean stomatogastric ganglion (STG), the gastric mill rhythm and the pyloric rhythm. Developmentally regulated changes in the modulatory functions of neuromodulators could therefore play an important role in the maturation of the output from the developing STG. We compared the effects of neuromodulators on isolated embryonic and adult STG of the lobster, Homarus americanus. Bath application of Val¹-SIFamide, a peptide whose expression is different in embryos and adults, activated different neuron classes in embryos and adults. Cancer borealis tachykinin-related peptide 1a, a peptide that does not appear in the terminals of modulatory neurons in the STG until after embryonic development, also produced different motor patterns in embryos and adults. In contrast, red pigment concentrating hormone, a peptide with a similar distribution in the STNS across development, produced similar motor patterns in embryonic and adult STG. Proctolin, serotonin, and allatostatin were also physiologically active on the isolated embryonic STG. Together, these results demonstrate that receptors to many neuromodulators are present and functional on STG neurons before the motor patterns of the stomatogastric nervous system are mature. Moreover, neuromodulator responses change during development, perhaps contributing to the maturation of the output from the stomatogastric nervous system.

Key words: central pattern generator; CabTRP1a; Val¹-SIFamide; RPCH; crustacean; maturation

---

Received May 22, 2008; revised July 3, 2008; accepted July 31, 2008.

Correspondence should be addressed to Kristina J. Rehm at her present address: Dana Farber Cancer Institute, 44 Binney Street, Dana 620, Boston, MA 02115. Email: Kristina_Rehm{at}DFCI.Harvard.edu

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help