WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, September 24, 2008, 28(39):9880-9889; doi:10.1523/JNEUROSCI.2401-08.2008

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Related articles in J. Neurosci.
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rattner, A.
Right arrow Articles by Nathans, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rattner, A.
Right arrow Articles by Nathans, J.

 Previous Article  |  Next Article 

Neurobiology of Disease
The Genomic Response of the Retinal Pigment Epithelium to Light Damage and Retinal Detachment

Amir Rattner,1 Leila Toulabi,1 John Williams,1,4 Huimin Yu,1 and Jeremy Nathans1,2,3,4

Departments of 1Molecular Biology and Genetics, 2Neuroscience, and 3Ophthalmology, and the 4Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Correspondence should be addressed to Dr. Jeremy Nathans, Johns Hopkins University School of Medicine, 805 PCTB, 725 North Wolfe Street, Baltimore, MD 21205. Email: jnathans{at}jhmi.edu

The retinal pigment epithelium (RPE) plays an essential role in maintaining the health of the retina. The RPE is also the site of pathologic processes in a wide variety of retinal disorders including monogenic retinal dystrophies, age-related macular degeneration, and retinal detachment. Despite intense interest in the RPE, little is known about its molecular response to ocular damage or disease. We have conducted a comprehensive analysis of changes in transcript abundance (the "genomic response") in the murine RPE after light damage. Several dozen transcripts, many related to cell–cell signaling, show significant increases in abundance in response to bright light; transcripts encoding visual cycle proteins show a decrease in abundance. Similar changes are induced by retinal detachment. Environmental and genetic perturbations that modulate the RPE response to bright light suggest that this response is controlled by the retina. In contrast to the response to bright light, the RPE response to retinal detachment overrides these modulatory affects.

Key words: retinal pigment epithelium; transcription; microarray; mouse; ocular disease; light damage; retinal detachment

Received May 28, 2008; revised July 14, 2008; accepted Aug. 20, 2008.

Correspondence should be addressed to Dr. Jeremy Nathans, Johns Hopkins University School of Medicine, 805 PCTB, 725 North Wolfe Street, Baltimore, MD 21205. Email: jnathans{at}jhmi.edu


Related articles in J. Neurosci.:

This Week in The Journal

J. Neurosci. 2008 28: i. [Full Text]  





-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-