WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, October 1, 2008, 28(40):10124-10133; doi:10.1523/JNEUROSCI.3769-08.2008

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liu, Z.
Right arrow Articles by Qiu, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, Z.
Right arrow Articles by Qiu, M.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Control of Precerebellar Neuron Development by Olig3 bHLH Transcription Factor

Zijing Liu,1 Hong Li,1 Xuemei Hu,1 Ling Yu,2 Hongbin Liu,2 Ruifa Han,3 Rita Colella,1 George D. Mower,1 Yiping Chen,2 and Mengsheng Qiu1,3

1Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Louisville, Kentucky 40202, 2Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70117, and 3Institute of Urological Surgery, Tianjin Medical University, Tianjin 300211, China

Correspondence should be addressed to Mengsheng Qiu at the above addresses. Email: m0qiu001{at}louisville.edu

The rhombic lip (RL) is the neuroepithelium immediately adjacent to the roof plate of the fourth ventricle, and it gives rise to various brainstem and cerebellar cell types. Our study shows that the bHLH (basic helix-loop-helix) transcription factor Olig3 is expressed in the progenitors of RL, and ablation of Olig3 significantly affects the development of RL. In Olig3–/– caudal RL, the expression level of Math1 in the dorsal interneuron 1 (dI1) domain is reduced, and the formation of four mossy-fiber nuclei is compromised; dI2–dI3 neurons are misspecified to dI4 interneurons, and the climbing-fiber neurons (inferior olive nucleus) are completely lost. In addition, the formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is also dependent on Olig3. Therefore, Olig3 plays an important role in the fate specification and differentiation of caudal RL-derived neurons.

Key words: bHLH; cell fate; rhombic lip; mossy-fiber nuclei; climbing-fiber nucleus; cerebellum

Received Aug. 10, 2008; accepted Aug. 30, 2008.

Correspondence should be addressed to Mengsheng Qiu at the above addresses. Email: m0qiu001{at}louisville.edu






 -
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-