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The Journal of Neuroscience, October 8, 2008, 28(41):10272-10277; doi:10.1523/JNEUROSCI.1531-08.2008

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Brief Communications
The Influence of FosB in the Nucleus Accumbens on Natural Reward-Related Behavior

Deanna L Wallace,^1,2 Vincent Vialou,^1,2 Loretta Rios,^1,2 Tiffany L. Carle-Florence,^1,2 Sumana Chakravarty,^1,2 Arvind Kumar,^1,2 Danielle L. Graham,^1,2 Thomas A. Green,^1,2 Anne Kirk,^1,2 Sergio D. Iñiguez,³ Linda I. Perrotti,^1,2,4 Michel Barrot,^1,2,5 Ralph J. DiLeone,^1,2,6 Eric J. Nestler,^1,2 and Carlos A. Bolaños-Guzmán^1,2,3

Departments of ¹Psychiatry and ²Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, ³Department of Psychology, Florida State University, Tallahassee, Florida 32306, ⁴Department of Psychology, The University of Texas at Arlington, Arlington, Texas 76019, ⁵Institut des Neurosciences Cellulaires et Intégratives Unité Mixte de Recherche 7168, Centre National de la Recherche Scientifique and University Louis Pasteur, 67084 Strasbourg, France, and ⁶Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508

Correspondence should be addressed to Carlos A. Bolanos at the above address. Email: bolanos{at}psy.fsu.edu

The transcription factor deltaFosB (FosB), induced in nucleus accumbens (NAc) by chronic exposure to drugs of abuse, has been shown to mediate sensitized responses to these drugs. However, less is known about a role for FosB in regulating responses to natural rewards. Here, we demonstrate that two powerful natural reward behaviors, sucrose drinking and sexual behavior, increase levels of FosB in the NAc. We then use viral-mediated gene transfer to study how such FosB induction influences behavioral responses to these natural rewards. We demonstrate that overexpression of FosB in the NAc increases sucrose intake and promotes aspects of sexual behavior. In addition, we show that animals with previous sexual experience, which exhibit increased FosB levels, also show an increase in sucrose consumption. This work suggests that FosB is not only induced in the NAc by drugs of abuse, but also by natural rewarding stimuli. Additionally, our findings show that chronic exposure to stimuli that induce FosB in the NAc can increase consumption of other natural rewards.

Key words: behavior; nucleus accumbens; obesity; reward; sex; sucrose; transcription factor

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Received April 8, 2008; revised July 25, 2008; accepted Aug. 21, 2008.

Correspondence should be addressed to Carlos A. Bolanos at the above address. Email: bolanos{at}psy.fsu.edu

This article has been cited by other articles:

				S. Zukerman, J. I. Glendinning, R. F. Margolskee, and A. Sclafani T1R3 taste receptor is critical for sucrose but not Polycose taste Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R866 - R876. [Abstract] [Full Text] [PDF]

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