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The Journal of Neuroscience, October 15, 2008, 28(42):10751-10765; doi:10.1523/JNEUROSCI.1106-08.2008

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Behavioral/Systems/Cognitive
Neural Correlates of Predictive and Postdictive Switching Mechanisms for Internal Models

Hiroshi Imamizu^1,2 and Mitsuo Kawato¹

¹Advanced Telecommunications Research Institute International, Computational Neuroscience Laboratories, and ²National Institute of Information and Communications Technology, Kyoto 619-0288, Japan

Correspondence should be addressed to Hiroshi Imamizu, National Institute of Information and Communications Technology, 2-2-2 Hikaridai, Keihanna Science City, Kyoto 619-0288, Japan. Email: imamizu{at}gmail.com

Switching of sensorimotor tasks may be classified into predictive switching based on contextual information and postdictive switching based on the error between sensorimotor feedback and predictions. We used functional neuroimaging to study the brain regions involved in each type of switching of internal models for visuomotor rotations (clockwise and counterclockwise rotations of visual feedback). The color of a cue presented before movement initiation corresponded to direction of rotation of the feedback in an instructed condition, but not in a noninstructed condition. Switching-related activity was identified as activity that transiently increased after the direction of rotation was changed. The switching-related activity in cue periods in the instructed condition, when a predictive switch is possible, was observed in the superior parietal lobule (SPL). However, the switching-related activity in feedback periods in the noninstructed condition, when prediction error is crucial for the postdictive switch, was observed in the inferior parietal lobule (IPL) and prefrontal cortex. The functional influence of the SPL on the lateral cerebellum, namely, a possible neural correlate for internal models, increased in the instructed condition, but the influence of the IPL on the cerebellum was increased in the noninstructed condition. We observed a rapid activity increase in the instructed condition and a gradual activity increase in the noninstructed condition mainly in the lateral occipito-temporal cortices (LOTC) and supplementary motor cortex (SMA). These results are consistent with separate mechanisms for predictive and postdictive switches and suggest that the LOTC and SMA receive output signals from appropriate internal models.

Key words: task switching; internal models; visuomotor rotation; contextual information; sensorimotor feedback; functional magnetic resonance imaging

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Received March 13, 2008; revised July 26, 2008; accepted Sept. 10, 2008.

Correspondence should be addressed to Hiroshi Imamizu, National Institute of Information and Communications Technology, 2-2-2 Hikaridai, Keihanna Science City, Kyoto 619-0288, Japan. Email: imamizu{at}gmail.com

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