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The Journal of Neuroscience, November 12, 2008, 28(46):11814-11818; doi:10.1523/JNEUROSCI.3768-08.2008

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Symposia and Mini-Symposia
New Developments in Sleep Research: Molecular Genetics, Gene Expression, and Systems Neurobiology

Thomas S. Kilduff,¹ Ed S. Lein,² Horacio de la Iglesia,³ Takeshi Sakurai,⁴ Ying-hui Fu,⁵ and Paul Shaw⁶

¹Biosciences Division, SRI International, Menlo Park, California 94025, ²Department of Neuroscience, Allen Institute for Brain Science, Seattle, Washington 98103, ³Department of Biology, University of Washington, Seattle, Washington 98195-1800, ⁴Department of Molecular Neuroscience and Integrative Physiology, Kanazawa University, Kanazawa 920-8640, Japan, ⁵Department of Neurology, University of California San Francisco School of Medicine, San Francisco, California 94158-2324, and ⁶Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110

Address correspondence to Dr. Thomas S. Kilduff, Biosciences Division, SRI International, Menlo Park, CA 94025. Email: thomas.kilduff{at}sri.com

Understanding the mechanisms that underlie the control of sleep and wakefulness is a major research area in neuroscience. This mini-symposium review highlights some recent developments at the gene, molecular, cellular, and systems levels that have advanced this field. The studies discussed below use organisms ranging from flies to humans and focus on the interaction between the sleep homeostatic and circadian systems, the consequences of mutations in genes involved in the circadian clock on sleep timing, the effects of sleep deprivation on brain gene expression, the discovery of "sleep active" neurons in the cerebral cortex, the role of the hypocretin/orexin system in the maintenance of sleep and wakefulness, and the interaction between sleep and learning.

Key words: homeostatic system; circadian system; sleep timing; sleep deprivation; hypocretin/orexin system; sleep and learning

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Received Aug. 10, 2008; revised Sept. 10, 2008; accepted Sept. 10, 2008.

Address correspondence to Dr. Thomas S. Kilduff, Biosciences Division, SRI International, Menlo Park, CA 94025. Email: thomas.kilduff{at}sri.com

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