QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, November 26, 2008, 28(48):12864-12867; doi:10.1523/JNEUROSCI.2413-08.2008

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Related articles in J. Neurosci. Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Shan, Q. Articles by Storm, D. R. Search for Related Content PubMed PubMed Citation Articles by Shan, Q. Articles by Storm, D. R.

 Previous Article  |  Next Article 

Brief Communications
Type 1 Adenylyl Cyclase Is Essential for Maintenance of Remote Contextual Fear Memory

Qiang Shan, Guy C.-K. Chan, and Daniel R. Storm

Department of Pharmacology, University of Washington, Seattle, Washington 98195

Correspondence should be addressed to Daniel R. Storm at the above address. Email: dstorm{at}u.washington.edu

Although molecular mechanisms for hippocampus-dependent memory have been extensively studied, much less is known about signaling events important for remote memory. Here we report that mice lacking type 1 adenylyl cyclase (AC1) are able to establish and retrieve remote contextual memory but unable to sustain it as long as wild-type mice. Interestingly, mice overexpressing AC1 show superior remote contextual memory even though they exhibit normal hippocampus-dependent contextual memory. These data illustrate that calcium coupling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug target site to improve long-term remote memory.

Key words: calcium-sensitive adenylyl cyclase; anterior cingulate cortex; remote memory; contextual fear conditioning; memory maintenance; memory extinction

---

Received May 28, 2008; revised Sept. 9, 2008; accepted Oct. 11, 2008.

Correspondence should be addressed to Daniel R. Storm at the above address. Email: dstorm{at}u.washington.edu

Related articles in J. Neurosci.:

This Week in The Journal

J. Neurosci. 2008 28: i. [Full Text]  

This article has been cited by other articles:

				M. G. Garelick, G. C. K. Chan, D. P. DiRocco, and D. R. Storm Overexpression of Type I Adenylyl Cyclase in the Forebrain Impairs Spatial Memory in Aged But Not Young Mice J. Neurosci., September 2, 2009; 29(35): 10835 - 10842. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help