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The Journal of Neuroscience, December 10, 2008, 28(50):13384-13389; doi:10.1523/JNEUROSCI.4343-08.2008

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Brief Communications
NMDA Receptor Gating of Information Flow through the Striatum In Vivo

Pablo E. Pomata, Mariano A. Belluscio, Luis A. Riquelme, and M. Gustavo Murer

Laboratorio de Fisiología de Circuitos Neuronales, Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad de Buenos Aires, Ciudad de Buenos Aires (CP1121), Argentina

Correspondence should be addressed to Pablo E. Pomata,Laboratorio de Fisiología de Circuitos Neuronales, Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Ciudad de Buenos Aires (CP1121), Argentina. Email: neurofis{at}fmed.uba.ar

A role of NMDA receptors in corticostriatal synaptic plasticity is widely acknowledged. However, the conditions that allow NMDA receptor activation in the striatum in vivo remain obscure. Here we show that NMDA receptors contribute to sustain the membrane potential of striatal medium spiny projection neurons close to threshold during spontaneous UP states in vivo. Moreover, we found that the blockade of striatal NMDA receptors reduces markedly the spontaneous firing of ensembles of medium spiny neurons during slow waves in urethane-anesthetized rats. We speculate that recurrent activation of NMDA receptors during UP states allows off-line information flow through the striatum and system level consolidation during habit formation.

Key words: NMDA receptor; striatum; frontal cortex; slow waves; UP states; basal ganglia

Received Sept. 11, 2008; accepted Oct. 7, 2008.

Correspondence should be addressed to Pablo E. Pomata,Laboratorio de Fisiología de Circuitos Neuronales, Departamento de Fisiología y Biofísica, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, Ciudad de Buenos Aires (CP1121), Argentina. Email: neurofis{at}fmed.uba.ar




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