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The Journal of Neuroscience, December 10, 2008, 28(50):13419-13427; doi:10.1523/JNEUROSCI.1916-08.2008

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Behavioral/Systems/Cognitive
Neural Markers of Inhibition in Human Memory Retrieval

Maria Wimber,^1,2 Karl-Heinz Bäuml,² Zara Bergström,¹ Gerasimos Markopoulos,¹ Hans-Jochen Heinze,¹ and Alan Richardson-Klavehn¹

¹Department of Neurology, Otto von Guericke University, 39120 Magdeburg, Germany, and ²Department of Experimental Psychology, University of Regensburg, Germany

Correspondence should be addressed to Maria Wimber, Department of Neurology, Zenit 1 Building, Faculty of Medicine, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany. Email: wimber{at}med.ovgu.de

Retrieving particular information from memory facilitates the later retrieval of that information, but also impairs the later retrieval of related, interfering information. It has been theorized that this retrieval-induced forgetting reflects inhibition of interfering memory representations. We used event-related fMRI to investigate the functional neuroanatomy of this impaired retrieval, at the time the impairment is observed. Neural activity differences between impaired and facilitated information occurred in left ventrolateral prefrontal cortex (VLPFC, BA 45 and 47), precuneus (BA 7), and right inferior parietal lobule (IPL, BA 40). Activity in left anterior VLPFC (BA 47) and left posterior temporal cortex (BA 22), regions implicated in the controlled retrieval of weak semantic memory representations, predicted the degree of retrieval-induced forgetting. In contrast, activity in precuneus and right IPL predicted the degree of retrieval-induced facilitation. Our findings demonstrate that impairment of interfering memories and facilitation of practiced memories involve distinct neural processes, and suggest that the impairment reflects inhibition that weakens interfering memory representations.

Key words: fMRI; memory; inhibition; interference; cognitive control; VLPFC

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Received Sept. 5, 2008; accepted Oct. 27, 2008.

Correspondence should be addressed to Maria Wimber, Department of Neurology, Zenit 1 Building, Faculty of Medicine, Otto von Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany. Email: wimber{at}med.ovgu.de

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