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The Journal of Neuroscience, December 10, 2008, 28(50):13615-13620; doi:10.1523/JNEUROSCI.3303-08.2008

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Brief Communications
Differential Recruitment of Anterior Intraparietal Sulcus and Superior Parietal Lobule during Visually Guided Grasping Revealed by Electrical Neuroimaging

Eugene Tunik,¹ Stephanie Ortigue,² Serge V. Adamovich,³ and Scott T. Grafton²

¹Department of Rehabilitation and Movement Science, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07107, ²Department of Psychology, 4D Brain Electrodynamics Laboratory, University of California, Santa Barbara, Santa Barbara, California 93106, and ³Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102-1982

Correspondence should be addressed to Dr. Scott T. Grafton, UCSB Brain Imaging Center, Department of Psychology, University of California, Santa Barbara, Santa Barbara, CA 93106. Email: grafton{at}psych.ucsb.edu

Dorsal parietal cortex is required for visually guided prehension. Transcranial magnetic stimulation to either the anterior intraparietal sulcus (aIPS) or superior parietal lobule (SPL) disrupts on-line adaptive adjustments of grasp when objects are perturbed. We used high-density electroencephalography during grasping to determine the relative timing of these two areas and to test whether the temporal contribution of each site would change when the task goal was perturbed. During object grasping with the right-hand, two distinct evoked responses were present over the 50–100 and 100–200 ms periods after movement onset. Distributed linear source estimation of these scalp potentials localized left lateralized sources, first in the aIPS and then the SPL. The duration of the response from the aIPS area was longer when there was an object perturbation. Initiation of a corrective movement coincided with activation in SPL. These data support a two-stage process: the integration of target goal and an emerging action plan within aIPS and subsequent on-line adjustments within SPL.

Key words: reaching; motor cognition; event-related potentials; human; brain microstates; brain plasticity

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Received July 15, 2008; revised Nov. 4, 2008; accepted Nov. 6, 2008.

Correspondence should be addressed to Dr. Scott T. Grafton, UCSB Brain Imaging Center, Department of Psychology, University of California, Santa Barbara, Santa Barbara, CA 93106. Email: grafton{at}psych.ucsb.edu

This article has been cited by other articles:

				N. Gosselin-Kessiby, J. F. Kalaska, and J. Messier Evidence for a Proprioception-Based Rapid On-Line Error Correction Mechanism for Hand Orientation during Reaching Movements in Blind Subjects J. Neurosci., March 18, 2009; 29(11): 3485 - 3496. [Abstract] [Full Text] [PDF]

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