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The Journal of Neuroscience, December 17, 2008, 28(51):13716-13726; doi:10.1523/JNEUROSCI.2940-08.2008

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Cellular/Molecular
Region-Specific Spike-Frequency Acceleration in Layer 5 Pyramidal Neurons Mediated by Kv1 Subunits

Mark N. Miller, Benjamin W. Okaty, and Sacha B. Nelson

Biology Department, Brandeis University, Waltham, Massachusetts 02453

Correspondence should be addressed to Sacha B. Nelson, Biology Department, MS-008, Brandeis University, 415 South Street, Waltham, MA 02453. Email: nelson{at}brandeis.edu

Separation of the cortical sheet into functionally distinct regions is a hallmark of neocortical organization. Cortical circuit function emerges from afferent and efferent connectivity, local connectivity within the cortical microcircuit, and the intrinsic membrane properties of neurons that comprise the circuit. While localization of functions to particular cortical areas can be partially accounted for by regional differences in both long range and local connectivity, it is unknown whether the intrinsic membrane properties of cortical cell types differ between cortical regions. Here we report the first example of a region-specific firing type in layer 5 pyramidal neurons, and show that the intrinsic membrane and integrative properties of a discrete subtype of layer 5 pyramidal neurons differ between primary motor and somatosensory cortices due to region- and cell-type-specific Kv1 subunit expression.

Key words: neocortex; Kv1; firing type; pyramidal cell; motor cortex; electrophysiology

Received June 25, 2008; revised Oct. 15, 2008; accepted Oct. 15, 2008.

Correspondence should be addressed to Sacha B. Nelson, Biology Department, MS-008, Brandeis University, 415 South Street, Waltham, MA 02453. Email: nelson{at}brandeis.edu


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A. Groh, H. S. Meyer, E. F. Schmidt, N. Heintz, B. Sakmann, and P. Krieger
Cell-Type Specific Properties of Pyramidal Neurons in Neocortex Underlying a Layout that Is Modifiable Depending on the Cortical Area
Cereb Cortex, July 30, 2009; (2009) bhp152v1.
[Abstract] [Full Text] [PDF]


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