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The Journal of Neuroscience, December 17, 2008, 28(51):13967-13977; doi:10.1523/JNEUROSCI.3834-08.2008

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Behavioral/Systems/Cognitive
Cortically Evoked Long-Lasting Inhibition of Pallidal Neurons in a Transgenic Mouse Model of Dystonia

Satomi Chiken,1 Pullanipally Shashidharan,2 and Atsushi Nambu1

1Division of System Neurophysiology, National Institute for Physiological Sciences and Department of Physiological Sciences, Graduate University for Advanced Studies, Myodaiji, Okazaki 444-8585, Japan, and 2Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029

Correspondence should be addressed to Dr. Atsushi Nambu, Division of System Neurophysiology, National Institute for Physiological Sciences and Department of Physiological Sciences, Myodaiji, Okazaki 444-8585, Japan. Email: nambu{at}nips.ac.jp

Dystonia is a neurological disorder characterized by sustained or repetitive involuntary muscle contractions and abnormal postures. To understand the pathophysiology of dystonia, neurophysiological analyses were performed on hyperkinetic transgenic mice generated as a model of DYT1 dystonia. Abnormal muscle activity, such as coactivation of agonist and antagonist muscles and sustained muscle activation, was frequently observed in these mice. Recording of neuronal activity in the awake state revealed reduced spontaneous activity with bursts and pauses in both the external and internal segments of the globus pallidus. Motor cortical stimulation evoked responses composed of excitation and subsequent long-lasting inhibition in both pallidal segments, which were never observed in the normal mice. In addition, the somatotopic arrangements in both pallidal segments were disorganized. Long-lasting inhibition induced by cortical inputs in the internal pallidal segment may disinhibit thalamic and cortical activity, resulting in the motor hyperactivity observed in the transgenic mice.

Key words: dystonia; transgenic mouse model; extracellular recording; globus pallidus; movement disorders; basal ganglia

Received Aug. 12, 2008; revised Oct. 13, 2008; accepted Nov. 4, 2008.

Correspondence should be addressed to Dr. Atsushi Nambu, Division of System Neurophysiology, National Institute for Physiological Sciences and Department of Physiological Sciences, Myodaiji, Okazaki 444-8585, Japan. Email: nambu{at}nips.ac.jp






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