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The Journal of Neuroscience, January 7, 2009, 29(1):169-178; doi:10.1523/JNEUROSCI.3054-08.2009

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Development/Plasticity/Repair
Dynamic Changes in Brain Activity during Prism Adaptation

Jacques Luauté,^1,2,3 Sophie Schwartz,³ Yves Rossetti,^1,2 Mona Spiridon,³ Gilles Rode,^1,2 Dominique Boisson,^1,2 and Patrik Vuilleumier³

¹Université de Lyon, Université Lyon 1, Inserm UMR-S 864, 69500 Bron, France, ²Hospices Civils de Lyon, Service de Rééducation Neurologique, Plateforme ‘Mouvement et Handicap’, Hôpital Henry Gabrielle, 69230 Saint-Genis-Laval, France, and ³Laboratoire de Neurologie du Comportement et Neuro-Imagerie Cognitive, Département de Neuroscience, Centre Médical Universitaire, CH-1211 Geneva, Switzerland

Correspondence should be addressed to Dr. Jacques Luauté, Service de Rééducation Neurologique, Mouvement et Handicap, Hospices Civils de Lyon, Hôpital Henry Gabrielle, 69230 Saint Genis Laval, France. Email: jacques.luaute{at}chu-lyon.fr

Prism adaptation does not only induce short-term sensorimotor plasticity, but also longer-term reorganization in the neural representation of space. We used event-related fMRI to study dynamic changes in brain activity during both early and prolonged exposure to visual prisms. Participants performed a pointing task before, during, and after prism exposure. Measures of trial-by-trial pointing errors and corrections allowed parametric analyses of brain activity as a function of performance. We show that during the earliest phase of prism exposure, anterior intraparietal sulcus was primarily implicated in error detection, whereas parieto-occipital sulcus was implicated in error correction. Cerebellum activity showed progressive increases during prism exposure, in accordance with a key role for spatial realignment. This time course further suggests that the cerebellum might promote neural changes in superior temporal cortex, which was selectively activated during the later phase of prism exposure and could mediate the effects of prism adaptation on cognitive spatial representations.

Key words: plasticity; fMRI; adaptation; cerebellum; spatial cognition; parietal

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Received July 2, 2008; revised Nov. 10, 2008; accepted Nov. 14, 2008.

Correspondence should be addressed to Dr. Jacques Luauté, Service de Rééducation Neurologique, Mouvement et Handicap, Hospices Civils de Lyon, Hôpital Henry Gabrielle, 69230 Saint Genis Laval, France. Email: jacques.luaute{at}chu-lyon.fr

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