QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, April 1, 2009, 29(13):4140-4154; doi:10.1523/JNEUROSCI.5264-08.2009

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Karson, M. A. Articles by Alger, B. E. Search for Related Content PubMed PubMed Citation Articles by Karson, M. A. Articles by Alger, B. E.

 Previous Article  |  Next Article 

Cellular/Molecular
Synaptic Cross Talk between Perisomatic-Targeting Interneuron Classes Expressing Cholecystokinin and Parvalbumin in Hippocampus

Miranda A. Karson,^1 * Ai-Hui Tang,^1 * Teresa A. Milner,^2,3 and Bradley E. Alger¹

¹Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21210, ²Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, New York 10065, and ³Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065

Correspondence should be addressed to Dr. Bradley E. Alger, Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21210. Email: balgerlab{at}gmail.com

Cholescystokinin (CCK)- or parvalbumin (PV)-containing interneurons are the major perisomatic-targeting interneurons in the cerebral cortex, including hippocampus, and are thought to form mutually exclusive networks. We used several techniques to test the alternative hypothesis that CCK and PV cells are coupled by chemical synapses. Triple immunofluorescence confocal microscopy revealed numerous axosomatic, axodendritic, and axoaxonic contacts stained for CCK, PV, and the presynaptic marker synaptophysin. The existence of mutual CCK and PV synapses was supported by dual EM immunolabeling. Paired whole-cell recordings detected unitary GABA_Aergic synaptic transmission between identified CCK and PV cells, and single CCK cells could transiently inhibit action potential firing of synaptically coupled PV cells. We conclude that the major hippocampal perisomatic-targeting interneurons communicate synaptically. This communication should affect neuronal network activity, including neuronal oscillations, in which the CCK and PV cells have well established roles. The prevalence of CCK and PV networks in other brain regions suggests that internetwork interactions could be generally important.

---

Received Oct. 31, 2008; revised Feb. 7, 2009; accepted Feb. 19, 2009.

Correspondence should be addressed to Dr. Bradley E. Alger, Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21210. Email: balgerlab{at}gmail.com

This article has been cited by other articles:

				M. I. Daw, L. Tricoire, F. Erdelyi, G. Szabo, and C. J. McBain Asynchronous Transmitter Release from Cholecystokinin-Containing Inhibitory Interneurons Is Widespread and Target-Cell Independent J. Neurosci., September 9, 2009; 29(36): 11112 - 11122. [Abstract] [Full Text] [PDF]

				S. M. Eggan, Y. Mizoguchi, S. R. Stoyak, and D. A. Lewis Development of Cannabinoid 1 Receptor Protein and Messenger RNA in Monkey Dorsolateral Prefrontal Cortex Cereb Cortex, August 24, 2009; (2009) bhp179v1. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help