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The Journal of Neuroscience, April 8, 2009, 29(14):4351-4355; doi:10.1523/JNEUROSCI.0035-09.2009

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Brief Communications
An Oligovascular Niche: Cerebral Endothelial Cells Promote the Survival and Proliferation of Oligodendrocyte Precursor Cells

Ken Arai and Eng H. Lo

Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129

Correspondence should be addressed to either Ken Arai or Eng H. Lo, Neuroprotection Research Laboratory, MGH East 149-2401, Charlestown, MA 02129, Email: karai{at}partners.org or Email: lo{at}helix.mgh.harvard.edu

We show that cerebral endothelial cells secrete trophic factors that support the survival and proliferation of rat oligodendrocyte precursor cells (OPCs). This OPC-supportive phenomenon was mediated by Akt and Src signaling pathways. Noncytotoxic levels of oxidative stress downregulate trophic factor production and disrupt the ability of cerebral endothelial cells to support OPCs. These data suggest that a novel oligovascular niche may be important for sustaining oligodendrocyte renewal and homeostasis in mammalian brain.

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Received Dec. 31, 2008; revised Feb. 23, 2009; accepted Feb. 24, 2009.

Correspondence should be addressed to either Ken Arai or Eng H. Lo, Neuroprotection Research Laboratory, MGH East 149-2401, Charlestown, MA 02129, Email: karai{at}partners.org or Email: lo{at}helix.mgh.harvard.edu

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