WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, April 22, 2009, 29(16):5202-5206; doi:10.1523/JNEUROSCI.4432-08.2009

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (1)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stagg, C. J.
Right arrow Articles by Johansen-Berg, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stagg, C. J.
Right arrow Articles by Johansen-Berg, H.

 Previous Article  |  Next Article 

Brief Communications
Polarity-Sensitive Modulation of Cortical Neurotransmitters by Transcranial Stimulation

Charlotte J. Stagg,1 Jonathan G. Best,1 Mary C. Stephenson,2 Jacinta O'Shea,1 Marzena Wylezinska,1,3 Z. Tamas Kincses,1 Peter G. Morris,2 Paul M. Matthews,1,4,5 and Heidi Johansen-Berg1

1Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Headington, Oxford OX3 9DU, United Kingdom, 2Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham NG7 2RD, United Kingdom, 3Biological Imaging Centre, Imaging Sciences Department, Medical Research Council Clinical Sciences Centre, Imperial College London, Hammersmith Campus, London W12 0NN, United Kingdom, 4Department of Clinical Neuroscience, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom, and 5GlaxoSmithKline Clinical Imaging Centre, Hammersmith Hospital, London W12 0NN, United Kingdom

Correspondence should be addressed to Dr. Charlotte J. Stagg, Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. Email: cstagg{at}fmrib.ox.ac.uk

Transcranial direct current stimulation (tDCS) modulates cortical excitability and is being used for human studies more frequently. Here we probe the underlying neuronal mechanisms by measuring polarity-specific changes in neurotransmitter concentrations using magnetic resonance spectroscopy (MRS). MRS provides evidence that excitatory (anodal) tDCS causes locally reduced GABA while inhibitory (cathodal) stimulation causes reduced glutamatergic neuronal activity with a highly correlated reduction in GABA, presumably due to the close biochemical relationship between the two neurotransmitters.

Received July 18, 2008; revised Feb. 4, 2009; accepted March 13, 2009.

Correspondence should be addressed to Dr. Charlotte J. Stagg, Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. Email: cstagg{at}fmrib.ox.ac.uk




This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Jefferson, S. Mistry, S. Singh, J. Rothwell, and S. Hamdy
Characterizing the application of transcranial direct current stimulation in human pharyngeal motor cortex
Am J Physiol Gastrointest Liver Physiol, December 1, 2009; 297(6): G1035 - G1040.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-