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The Journal of Neuroscience, June 10, 2009, 29(23):7549-7557; doi:10.1523/JNEUROSCI.2474-08.2009

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Development/Plasticity/Repair
Exercise Induces Cortical Plasticity after Neonatal Spinal Cord Injury in the Rat

Tina Kao,¹ Jed S. Shumsky,¹ Marion Murray,¹ and Karen A. Moxon^1,2

¹Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, and ²School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104

Correspondence should be addressed to Dr. Karen A. Moxon, School of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104. Email: km57{at}drexel.edu

Exercise-induced cortical plasticity is associated with improved functional outcome after brain or nerve injury. Exercise also improves functional outcomes after spinal cord injury, but its effects on cortical plasticity are not known. The goal of this investigation was to study the effect of moderate exercise (treadmill locomotion, 3 min/d, 5 d/week) on the somatotopic organization of forelimb and hindlimb somatosensory cortex (SI) after neonatal thoracic transection. We used adult rats spinalized as neonates because some of these animals develop weight-supported stepping, and, therefore, the relationship between cortical plasticity and stepping could also be examined. Acute, single-neuron mapping was used to determine the percentage of cortical cells responding to cutaneous forelimb stimulation in normal, spinalized, and exercised spinalized rats. Multiple single-neuron recording from arrays of chronically implanted microwires examined the magnitude of response of these cells in normal and exercised spinalized rats. Our results show that exercise not only increased the percentage of responding cells in the hindlimb SI but also increased the magnitude of the response of these cells. This increase in response magnitude was correlated with behavioral outcome measures. In the forelimb SI, neonatal transection reduced the percentage of responding cells to forelimb stimulation, but exercise reversed this loss. This restoration in the percentage of responding cells after exercise was accompanied by an increase in their response magnitude. Therefore, the increase in responsiveness of hindlimb SI to forelimb stimulation after neonatal transection and exercise may be due, in part, to the effect of exercise on the forelimb SI.

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Received June 2, 2008; revised April 8, 2009; accepted April 14, 2009.

Correspondence should be addressed to Dr. Karen A. Moxon, School of Biomedical Engineering, Science and Health Systems, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104. Email: km57{at}drexel.edu

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