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Journal of Neuroscience, Vol 3, 417-423, Copyright © 1983 by Society for Neuroscience
Hormonal control of a developing neuromuscular system. I. Complete Demasculinization of the male rat spinal nucleus of the bulbocavernosus using the anti-androgen flutamide
SM Breedlove and AP Arnold
Prenatal treatment of male rats with the anti-androgen, flutamide (FL),
demasculinizes the sexually dimorphic spinal nucleus of the bulbocavernosus
(SNB) by reducing the number of SNB neurons, the size of the somas and
nuclei of SNB neurons, and the size of their target muscles in adulthood.
However, FL does not affect mounting or the traditional, postural measure
of intromission, indicating that the SNB system does not play a major role
in the mediation of these particular behaviors. Postnatal testosterone
propionate (TP) treatment of male rats castrated on the day of birth
results in more male copulatory behaviors in adulthood and masculinizes all
measures of the SNB system. The postnatal masculinization by TP is more
pronounced in males treated prenatally with FL, for morphological but not
behavioral measures. The combined treatment of prenatal FL and day 1
castration without TP therapy results in a male with a completely
demasculinized SNB system. Specifically, such males have SNB neurons that
are as scarce and as small as those of females and, like females, they lack
the target muscles of the SNB. These results support the hypothesis that
perinatal androgens normally direct the sexually dimorphic development of
the SNB and its target muscles.
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