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Journal of Neuroscience, Vol 4, 1677-1682, Copyright © 1984 by Society for Neuroscience
The suprachiasmatic nuclei of the fetal rat: characterization of a functional circadian clock using 14C-labeled deoxyglucose
SM Reppert and WJ Schwartz
The circadian clock located in the suprachiasmatic nuclei (SCN) was
characterized in the fetal rat by using 14C-labeled deoxyglucose to monitor
glucose utilization (metabolic activity) of the nuclei. A clear day-night
oscillation of metabolic activity was detectable in the fetal SCN from the
19th through the 21st days of gestation; the nuclei were metabolically
active during the subjective day and metabolically inactive during the
subjective night. During the subjective day on gestational day 21, the
fetal SCN were found to manifest high metabolic activity for most of the
subjective day. We were able to acutely dissociate SCN metabolic activity
in the mother rat from that in the fetus by exposing the pregnant animals
to light during the normal dark period of diurnal lighting on gestational
day 20. The results show the utility of the deoxyglucose method for
directly investigating prenatally the function of the biological clock
located in the SCN.
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