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Journal of Neuroscience, Vol 5, 2169-2176, Copyright © 1985 by Society for Neuroscience
Depletion of norepinephrine, but not serotonin, reduces long-term potentiation in the dentate gyrus of rat hippocampal slices
PK Stanton and JM Sarvey
Long-term potentiation (LTP) in the hippocampus is a long-lasting
enhancement of synaptic efficacy produced by a brief, high frequency
repetitive stimulation of afferents. LTP has generated a great deal of
interest as a candidate mechanism in learning and memory. A recent in vivo
study has shown that depletion of norepinephrine (NE) or serotonin
(5-hydroxytryptamine, 5-HT) reduced LTP in the dentate gyrus produced by
stimulation of the perforant path. However, it was impossible to tell
whether this resulted from depletion in the hippocampus, itself, or was
secondary to depletion of other brain areas, and no comparison between
hippocampal cell fields was done. Therefore, we have examined the effects
of depletion of NE or 5-HT on LTP in the dentate and field CA1 of the
isolated in vitro hippocampal slice preparation. We report here that NE
depletion markedly reduces the occurrence and amplitude of LTP in the
dentate, but not in field CA1. In contrast, depletion of 5- HT does not
prevent occurrence of LTP in either area. Furthermore, pharmacologic data
indicate that beta-receptor stimulation of adenylate cyclase is probably
the mechanism of NE's action in the production of LTP in the dentate. These
results suggest that endogenous hippocampal NE is more important to LTP in
the dentate than is endogenous 5-HT.
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