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Journal of Neuroscience, Vol 5, 2345-2358, Copyright © 1985 by Society for Neuroscience
Growth cone morphology and trajectory in the lumbosacral region of the chick embryo
KW Tosney and LT Landmesser
We quantitatively analyzed several features of orthogradely labeled
peripheral growth cones in the lumbosacral region of the chick embryo. We
compared motoneuron growth cones in regions where they appear to express
specific directional preferences (the plexus region and regions where
muscle nerves diverge from main nerve trunks), which we operationally
defined as "decision regions," to motoneuron growth cones in other pathway
regions (the spinal nerve, nerve trunk, and muscle nerve pathways) which we
termed, for contrast, "non-decision region." We found that motoneuron
growth cones are larger, more lamellepodial, and have more complex
trajectories in decision regions. Sensory growth cone populations, which
are thought to be dependent upon motoneurons for outgrowth (Landmesser, L.,
and M. Honig (1982) Soc. Neurosci. Abstr. 8: 929), do not enlarge or become
more lamellepodial in motoneuron decision regions, suggesting that this
local environment does not affect all species of growth cones equally and
that the alterations in motoneuron growth cones in these regions may be
relevant to their specific guidance. In addition, the resemblance between
the sensory population and other closely fasciculating growth cones lends
support to the suggestion that sensory neurons utilize motoneuron neurites
as a substratum. We suggest that the convoluted trajectories, enlarged
size, and more lamellepodial morphology of motoneuron growth cones in
decision regions is either related directly to the presence of specific
cues that guide motoneurons or to some aspect of this environment that
allows them to respond to specific cues.
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