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Journal of Neuroscience, Vol 6, 3692-3705, Copyright © 1986 by Society for Neuroscience
Topographic targeting errors in the retinocollicular projection and their elimination by selective ganglion cell death
DD O'Leary, JW Fawcett and WM Cowan
In adult rats, as in other rodents, the retinocollicular projection is
topographically organized in a very precise manner. Experiments involving
the use of the retrogradely transported fluorescent dye fast blue as either
a short- or long-term marker in neonatal rats indicate that the precision
of this retinotopic projection does not arise ab initio, but rather is
brought about by the preferential elimination of those ganglion cells whose
axons project to topographically inappropriate regions of the colliculus.
Such topographic targeting errors have been identified along both the
rostrocaudal and mediolateral axes of the colliculus, and their elimination
occurs during the period of naturally occurring ganglion cell death, which
is completed by about postnatal day 10. When impulse activity in the
retinal ganglion cell axons is blocked by repeated intraocular injections
of the sodium channel-blocking agent tetrodotoxin (TTX) throughout the
postnatal period of ganglion cell death, the preferential loss of the
incorrectly projecting ganglion cells does not occur in the
activity-blocked eye, although, as reported elsewhere, the overall loss of
ganglion cells is comparable to that seen in normal animals. This supports
the notion that the mechanism for selecting against incorrectly projecting
ganglion cells is based on impulse activity among the competing ganglion
cell axons. However, under activity-block conditions, the aberrantly
projecting axons appear to retract from the caudal margin of the
colliculus. The death of retinal ganglion cells during development thus
seems to serve 2 purposes: It provides for the quantitative matching of the
ganglion cell population to the needs of its central projection fields,
and, at the same time, it serves to selectively eliminate those cells whose
axons project to inappropriate targets or to inappropriate regions within
the correct target fields.
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