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Journal of Neuroscience, Vol 6, 331-345, Copyright © 1986 by Society for Neuroscience
The rod pathway in the rabbit retina: a depolarizing bipolar and amacrine cell
RF Dacheux and E Raviola
Anatomical and electrophysiological techniques were combined to study the
morphology, synaptic connections, and response properties of two neurons in
the rod pathway of the rabbit retina: the rod bipolar cell and the
narrow-field, bistratified (NFB) amacrine cell. Rod bipolars receive
synaptic input from rod cells in the outer plexiform layer (OPL), where
their dendrites end as central elements in the invaginating synapse of rod
spherules. Their main synaptic output in the inner plexiform layer (IPL) is
onto NFB amacrine cells and at least one other type of amacrine, which in
turn feeds a reciprocal synapse back onto the bipolar endings. Rod
bipolars, or a variety of them, respond to diffuse, white light stimulation
with a transient-sustained depolarization dominated by rods; with
high-intensity flashes, they generate a secondary depolarization at off,
which is homologous to the rod aftereffect of horizontal cells, although
opposite in polarity. NFB amacrine cells receive synaptic input from rod
bipolars, cone bipolars, and other types of amacrine cells; they are
presynaptic to ganglion cell dendrites and communicate via gap junctions
with other processes, whose parent neuron has not yet been identified. They
respond to light with a triphasic potential, characterized by a
depolarizing transient at on, followed by a sustained plateau phase, and
finally by a hyperpolarizing transient at off. Threshold of their responses
is the same as in the depolarizing rod bipolars and saturation is reached
with nearly the same stimulus intensity in both neurons. Furthermore, NFB
amacrine cells exhibit a depolarizing rod aftereffect at the termination of
high-intensity flashes. Thus, this amacrine cell type is inserted in series
along the rod pathway in the rabbit retina and modulates the transfer of
scotopic signals from rod bipolars to ganglion cells.
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