 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 6, 346-354, Copyright © 1986 by Society for Neuroscience
Vestibular signals carried by pathways subserving plasticity of the vestibulo-ocular reflex in monkeys
SG Lisberger and TA Pavelko
The vestibulo-ocular reflex (VOR) is subject to long-term adaptive changes
that minimize retinal image slip and keep eye movement equal to and
opposite head movement. As a step toward identifying the site of neural
changes, we have used a transient vestibular stimulus to study the dynamic
response properties of the vestibular signals carried by the modifiable
pathways. In normal monkeys, "rapid changes in head velocity" (30
degrees/sec in 50 msec) evoke a VOR that has a slight overshoot and reaches
a steady-state gain (eye velocity divided by head velocity) of 1.0.
Adaptation to magnifying spectacles causes changes in both the steady-state
gain and the degree of overshoot in the eye velocity of the VOR. When the
steady-state gain is decreased, the transient overshoot increases, so that
peak eye velocity is twice steady-state. When the steady-state gain is
increased, the overshoot decreases, so that peak eye velocity is nearly
equal to steady-state. The discharge of vestibular primary afferents
suggests an explanation for the inverse relationship between the transient
overshoot and the steady-state gain of the VOR. In normal monkeys, 73
afferents showed a range of transient responses during rapid changes in
head velocity. The afferents with the most regular spontaneous discharge
had little overshoot in firing rate. Afferents with less regular discharge
had large overshoots in firing; the peak change in firing was 2-6 X the
steady-state change. We suggest that the large overshoot in eye velocity
when VOR gain is low represents the contribution of vestibular signals from
afferents with large transient responses.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
|
|
 
R. Ramachandran and S. G. Lisberger
Neural Substrate of Modified and Unmodified Pathways for Learning in Monkey Vestibuloocular Reflex
J Neurophysiol,
October 1, 2008;
100(4):
1868 - 1878.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F. Medina and S. G. Lisberger
Variation, Signal, and Noise in Cerebellar Sensory-Motor Processing for Smooth-Pursuit Eye Movements
J. Neurosci.,
June 20, 2007;
27(25):
6832 - 6842.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. G. Sadeghi, L. B. Minor, and K. E. Cullen
Response of Vestibular-Nerve Afferents to Active and Passive Rotations Under Normal Conditions and After Unilateral Labyrinthectomy
J Neurophysiol,
February 1, 2007;
97(2):
1503 - 1514.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. G. Sadeghi, M. J. Chacron, M. C. Taylor, and K. E. Cullen
Neural Variability, Detection Thresholds, and Information Transmission in the Vestibular System
J. Neurosci.,
January 24, 2007;
27(4):
771 - 781.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Ramachandran and S. G. Lisberger
Transformation of Vestibular Signals Into Motor Commands in the Vestibuloocular Reflex Pathways of Monkeys
J Neurophysiol,
September 1, 2006;
96(3):
1061 - 1074.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Ramachandran and S. G. Lisberger
Normal Performance and Expression of Learning in the Vestibulo-Ocular Reflex (VOR) at High Frequencies
J Neurophysiol,
April 1, 2005;
93(4):
2028 - 2038.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Carey and S. G. Lisberger
Signals That Modulate Gain Control for Smooth Pursuit Eye Movements in Monkeys
J Neurophysiol,
February 1, 2004;
91(2):
623 - 631.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. B. Yakushin, T. Raphan, and B. Cohen
Gravity-Specific Adaptation of the Angular Vestibuloocular Reflex: Dependence on Head Orientation With Regard to Gravity
J Neurophysiol,
January 1, 2003;
89(1):
571 - 586.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Clendaniel, D. M. Lasker, and L. B. Minor
Differential Adaptation of the Linear and Nonlinear Components of the Horizontal Vestibuloocular Reflex in Squirrel Monkeys
J Neurophysiol,
December 1, 2002;
88(6):
3534 - 3540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. E. Cullen and L. B. Minor
Semicircular Canal Afferents Similarly Encode Active and Passive Head-On-Body Rotations: Implications for the Role of Vestibular Efference
J. Neurosci.,
May 30, 2002;
(2002)
20026418.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tabata, K. Yamamoto, and M. Kawato
Computational Study on Monkey VOR Adaptation and Smooth Pursuit Based on the Parallel Control-Pathway Theory
J Neurophysiol,
April 1, 2002;
87(4):
2176 - 2189.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Rambold, A. Churchland, Y. Selig, L. Jasmin, and S. G. Lisberger
Partial Ablations of the Flocculus and Ventral Paraflocculus in Monkeys Cause Linked Deficits in Smooth Pursuit Eye Movements and Adaptive Modification of the VOR
J Neurophysiol,
February 1, 2002;
87(2):
912 - 924.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Clendaniel, D. M. Lasker, and L. B. Minor
Horizontal Vestibuloocular Reflex Evoked by High-Acceleration Rotations in the Squirrel Monkey. IV. Responses After Spectacle-Induced Adaptation
J Neurophysiol,
October 1, 2001;
86(4):
1594 - 1611.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hirata and S. M. Highstein
Acute Adaptation of the Vestibuloocular Reflex: Signal Processing by Floccular and Ventral Parafloccular Purkinje Cells
J Neurophysiol,
May 1, 2001;
85(5):
2267 - 2288.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Collewijn and J. B. J. Smeets
Early Components of the Human Vestibulo-Ocular Response to Head Rotation: Latency and Gain
J Neurophysiol,
July 1, 2000;
84(1):
376 - 389.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. B. Minor, D. M. Lasker, D. D. Backous, and T. E. Hullar
Horizontal Vestibuloocular Reflex Evoked by High-Acceleration Rotations in the Squirrel Monkey. I. Normal Responses
J Neurophysiol,
September 1, 1999;
82(3):
1254 - 1270.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Raymond and S. G. Lisberger
Neural Learning Rules for the Vestibulo-Ocular Reflex
J. Neurosci.,
November 1, 1998;
18(21):
9112 - 9129.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Raymond and S. G. Lisberger
Behavioral Analysis of Signals that Guide Learned Changes in the Amplitude and Dynamics of the Vestibulo-Ocular Reflex
J. Neurosci.,
December 1, 1996;
16(23):
7791 - 7802.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.G. Lisberger, D.M. Broussard, and H.M. Bronte-Stewart
Properties of Pathways That Mediate Motor Learning in the Vestibulo-ocular Reflex of Monkeys
Cold Spring Harb Symp Quant Biol,
January 1, 1990;
55(0):
813 - 822.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Lisberger
The neural basis for learning of simple motor skills
Science,
November 4, 1988;
242(4879):
728 - 735.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Lisberger and T. Pavelko
Brain stem neurons in modified pathways for motor learning in the primate vestibulo-ocular reflex
Science,
November 4, 1988;
242(4879):
771 - 773.
[Abstract]
[PDF]
|
|
|
|
