WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience Imaging at the Speed of Life
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kunkel, D. D.
Right arrow Articles by Schwartzkroin, P. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kunkel, D. D.
Right arrow Articles by Schwartzkroin, P. A.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 6, 541-552, Copyright © 1986 by Society for Neuroscience

ARTICLE

Glutamic acid decarboxylase (GAD) immunocytochemistry of developing rabbit hippocampus

DD Kunkel, AE Hendrickson, JY Wu and PA Schwartzkroin

Immunocytochemical techniques were used to examine the synaptic relations of inhibitory interneurons in the developing rabbit hippocampus. Glutamic acid decarboxylase (GAD), the synthesizing enzyme for the inhibitory neurotransmitter GABA, was found in interneurons of immature (8 d old) as well as mature (30 d old) tissue. GAD- immunoreactivity was seen in somata, dendrites, and axon terminals of interneurons at both ages. Electron-microscopic examination revealed that GAD-positive "terminals" in immature tissue were often not associated with the usual synaptic specializations, but were rather in simple apposition to the "postsynaptic" element. In mature tissue, GAD- positive terminals made symmetric contacts primarily with pyramidal cell somata, initial segments, and proximal dendrites. In addition, GAD- positive terminals synapsed onto both GAD-positive and GAD-negative interneuron profiles.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
A. Azimi-Zonooz, C. W. Shuttleworth, and J. A. Connor
GABAergic Protection of Hippocampal Pyramidal Neurons Against Glutamate Insult: Deficit in Young Animals Compared to Adults
J Neurophysiol, July 1, 2006; 96(1): 299 - 308.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Hering and M. Sheng
Activity-Dependent Redistribution and Essential Role of Cortactin in Dendritic Spine Morphogenesis
J. Neurosci., December 17, 2003; 23(37): 11759 - 11769.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. R. Svoboda and C. R. Lupica
Opioid Inhibition of Hippocampal Interneurons via Modulation of Potassium and Hyperpolarization-Activated Cation (Ih) Currents
J. Neurosci., September 15, 1998; 18(18): 7084 - 7098.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. B. Bausch and C. Chavkin
Changes in Hippocampal Circuitry after Pilocarpine-Induced Seizures as Revealed by Opioid Receptor Distribution and Activation
J. Neurosci., January 1, 1997; 17(1): 477 - 492.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
Z. B. Yao, X. Li, Z. C. Xu, and J. T. Povlishock
GABAergic and Asymmetrical Synapses on Somata of GABAergic Neurons in CA1 and CA3 Regions of Rat Hippocampus: A Quantitative Electron Microscopic Analysis
Stroke, August 1, 1996; 27(8): 1411 - 1416.
[Abstract] [Full Text]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-