 |
 Previous Article | Next Article 
Journal of Neuroscience, Vol 6, 739-758, Copyright © 1986 by Society for Neuroscience
Differential distribution of cell adhesion molecules during histogenesis of the chick nervous system
JK Daniloff, CM Chuong, G Levi and GM Edelman
We have compared the expression of the neural cell adhesion molecule (N-
CAM) and the neuron-glial cell adhesion molecule (Ng-CAM) during
histogenesis of the chick nervous system. Data from immunohistochemistry
and photometry were combined to construct maps of the overall distribution
and dynamics of CAM appearance and disappearance. Each CAM appeared in a
characteristic spatial and temporal pattern in various areas during cell
movement, fiber outgrowth, tract formation, and myelination. N-CAM was more
uniformly distributed than Ng-CAM and was present on all neural cell bodies
and processes of the CNS and PNS. In the adult, the staining pattern of N-
CAM remained similar to that in the embryo, although the staining intensity
was diminished. During embryonic development, Ng-CAM was expressed on
extending neurites and migrating neurons. The appearance Ng-CAM in the CNS
was correlated particularly with times of cell migration in spinal cord and
cerebellum, and in regions undergoing neurite extension, such as the
developing white matter of the spinal cord, the optic nerve, and the medial
longitudinal fasciculus. Cell bodies not undergoing migration were negative
for Ng-CAM. In the adult CNS, Ng-CAM was markedly decreased in myelinated
fiber tracts like the white matter of the spinal cord but persisted in
unmyelinated regions such as the olfactory bulb. In contrast, in the PNS
(for example, the dorsal root ganglion and sciatic nerve), Ng-CAM appeared
early on both cell bodies and neurites, and it continued to be present on
both in the adult, even in the presence of myelin. Maps comparing the
relative distribution of Ng-CAM and N-CAM showed dynamic reversals as the
nervous system developed and, as a result, the pattern of CAM expression
was markedly different in embryos and adults. This difference appears to
reflect changes in the roles of selective adhesion and of the two neuronal
CAMs at different times of development.
This article has been cited by other articles:
|
|
|
|
 
M. L. Lemons, S. Barua, M. L. Abanto, W. Halfter, and M. L. Condic
Adaptation of Sensory Neurons to Hyalectin and Decorin Proteoglycans
J. Neurosci.,
May 18, 2005;
25(20):
4964 - 4973.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kunz, M. Spirig, C. Ginsburg, A. Buchstaller, P. Berger, R. Lanz, C. Rader, L. Vogt, B. Kunz, and P. Sonderegger
Neurite Fasciculation Mediated by Complexes of Axonin-1 and Ng Cell Adhesion Molecule
J. Cell Biol.,
December 14, 1998;
143(6):
1673 - 1690.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. M. Yip, X. Zhao, A. M.P. Montgomery, and C.-H. Siu
The Arg-Gly-Asp Motif in the Cell Adhesion Molecule L1 Promotes Neurite Outgrowth via Interaction with the alpha vbeta 3 Integrin
Mol. Biol. Cell,
February 1, 1998;
9(2):
277 - 290.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
A. Chedotal, O. Pourquie, F. Ezan, H. San Clemente, and C. Sotelo
BEN As a Presumptive Target Recognition Molecule during the Development of the Olivocerebellar System
J. Neurosci.,
May 15, 1996;
16(10):
3296 - 3310.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Kallunki, S. Jenkinson, G. M. Edelman, and F. S. Jones
Silencer Elements Modulate the Expression of the Gene for the Neuron-Glia Cell Adhesion Molecule, Ng-CAM
J. Biol. Chem.,
September 8, 1995;
270(36):
21291 - 21298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Stoker, B Gehrig, F Haj, and B. Bay
Axonal localisation of the CAM-like tyrosine phosphatase CRYP alpha: a signalling molecule of embryonic growth cones
Development,
January 6, 1995;
121(6):
1833 - 1844.
[Abstract]
[PDF]
|
|
|
|
|
|
|
H Stier and B Schlosshauer
Axonal guidance in the chicken retina
Development,
January 5, 1995;
121(5):
1443 - 1454.
[Abstract]
[PDF]
|
|
|
|
|
|
|
L Bally-Cuif, C Goridis, and M. Santoni
The mouse NCAM gene displays a biphasic expression pattern during neural tube development
Development,
January 2, 1993;
117(2):
543 - 552.
[Abstract]
[PDF]
|
|
|
|
