QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (48) Citing Articles via Google Scholar Google Scholar Articles by Yu, W. H. Articles by McGinnis, M. Y. Search for Related Content PubMed PubMed Citation Articles by Yu, W. H. Articles by McGinnis, M. Y.

 Previous Article  |  Next Article 

Journal of Neuroscience, Vol 6, 1302-1307, Copyright © 1986 by Society for Neuroscience

ARTICLE

Androgen receptor levels in cranial nerve nuclei and tongue muscles in rats

WH Yu and MY McGinnis

Specific in vitro binding of 3H-methyltrienolone (R1881) was demonstrated in 100,000 X g supernatant (cytosol) of hypoglossal, facial, and cochlear nuclei and tongue muscles of adult rats. Binding sites in these cranial nerve nuclei and tongue muscles were of high affinity, limited capacity, with steroid specificity; and they were capable of translocation to the cell nuclei in vivo. Accordingly, an androgen receptor system with properties very much akin to the androgen receptors described in the forebrain limbic regions has been quantitatively demonstrated for the first time in brain stem nuclei. Because of its widespread presence in neurons of the brain stem and spinal cord, androgen receptors may have important roles in regulation of neuron physiology beyond the sphere of reproductive function, including mediating androgen effects on regeneration of the hypoglossal nerve reported previously.

This article has been cited by other articles:

				S. Vucic and M. C. Kiernan Pathophysiologic insights into motor axonal function in Kennedy disease Neurology, November 6, 2007; 69(19): 1828 - 1835. [Abstract] [Full Text] [PDF]

				N. G. Forger, C. K. Wagner, M. Contois, L. Bengston, and A. J. MacLennan Ciliary Neurotrophic Factor Receptor alpha  in Spinal Motoneurons is Regulated by Gonadal Hormones J. Neurosci., November 1, 1998; 18(21): 8720 - 8729. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help