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Journal of Neuroscience, Vol 6, 1575-1582, Copyright © 1986 by Society for Neuroscience
Hippocampal long-lasting potentiation produced by pairing single volleys and brief conditioning tetani evoked in separate afferents
B Gustafsson and H Wigstrom
Cooperative effects between afferents on the induction of long-lasting
potentiation (LLP) of synaptic transmission were examined in the CA1 region
of the hippocampal slice preparation. Synaptic activity was recorded
extracellularly in the dendritic layer (stratum radiatum) as a field EPSP,
and the amount of LLP produced was measured from the change in slope of the
rising phase of this potential. Experiments were performed with the GABA
antagonist picrotoxin in the bath solution in order to facilitate the
induction of LLP. It is shown that under these conditions a test input
evoked by single volleys (at 0.2 Hz) is potentiated when paired with brief
tetani (2-15 impulses at 50 Hz) to a separate population of fibers in the
stratum radiatum. For this potentiation to appear, the test input had to
occur during the train or precede it by less than 40 msec. Maximal effects
were observed with the test volley positioned in the early part of the
tetanus, and were largely independent of train duration. The potentiation
obtained in this manner reached a peak level after some 20 conjunction
events, and its magnitude measured 10 min after conjunction was about half
that which could be induced by homosynaptic tetanization. Prior
homosynaptic potentiation occluded the potentiation induced by conjunction,
suggesting an identity of their underlying mechanisms. A test input to the
apical dendritic layer was potentiated also by inputs to the basal
dendritic layer, although greater effects were observed with both inputs in
the same dendritic layer. It is suggested that the conditioning effect is
related to the postsynaptic depolarization created by the tetanus.(ABSTRACT
TRUNCATED AT 250 WORDS)
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