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Journal of Neuroscience, Vol 6, 2403-2415, Copyright © 1986 by Society for Neuroscience
Activity of an identified histaminergic neuron, and its possible role in arousal of feeding behavior in semi-intact Aplysia
KR Weiss, HJ Chiel, U Koch and I Kupfermann
The possible functions of histaminergic neuron C2 were studied in an
isolated head preparation from which it was possible to obtain
intracellular recordings while the buccal mass exhibited feeding-like
responses. Application of food to the lips of the isolated head preparation
elicited rhythmic buccal movements that appeared to be ingestion responses,
since they moved seaweed into the buccal cavity and towards the esophagus,
and their frequency and regularity was similar to the ingestion responses
studied in a group of intact animals. The ingestion responses of the buccal
mass consisted of 2 main phases of movement of the radula from a middle
rest position: forward and return to rest, and backward and return to rest.
The relative magnitudes and timing of these 2 phases were variable.
Intracellular recordings from C2 in the isolated head revealed that C2 is
silent when the buccal mass is quiescent, but that it can be excited into
spike activity, either by mechanical stimulation of the perioral zone or by
chemostimulation that results in rhythmic movement. C2 fires a burst of
spikes in phase with each protraction-retraction cycle, and, if the
movements continue, C2 fires even when the eliciting stimulus has been
removed. Activity of the cell was usually preceded by fast depolarizing
responses that appeared to be blocked axon spikes. The evidence suggests
that C2 is part of a positive feedback loop that may help maintain the
persistence of arousal of feeding behavior beyond the time that food
stimuli are removed.
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