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Journal of Neuroscience, Vol 7, 201-212, Copyright © 1987 by Society for Neuroscience
Collapse of growth cone structure on contact with specific neurites in culture
JP Kapfhammer and JA Raper
We have studied the morphology of embryonic chick retinal and sympathetic
growth cones as they meet retinal and sympathetic neurites grown in
culture. Growth cones preserve their normal morphology and ability to
locomote when retinal growth cones contact retinal neurites or when
sympathetic growth cones contact sympathetic neurites. Growth cones
collapse and their motility ceases when retinal growth cones contact
sympathetic neurites or when sympathetic growth cones contact retinal
neurites. Collapse was never observed before a growth cone touched a
neurite. As a growth cone collapses, the neurite it leads retracts. After a
brief pause, a new growth cone is organized and extension recommences.
These results suggest that contact-mediated inhibition of locomotion could
play a role in growth cone guidance.
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