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Journal of Neuroscience, Vol 7, 2991-3001, Copyright © 1987 by Society for Neuroscience

ARTICLE

Fetal frontal cortex transplanted to injured motor/sensory cortex of adult rats. I. NADPH-diaphorase neurons

MF Gonzalez and FR Sharp
Department of Neurology, University of California, San Francisco.

Fetal frontal cortex from 18-d-old embryonic rat brain was transplanted into cavities of juvenile host motor/sensory cortex. Two to seven months later, sections were reacted for NADPH-diaphorase (NADPH-d) enzyme histochemistry. NADPH-d-positive neurons survived in 11 of 13 grafts. All but one of the transplants had reduced numbers of these neurons, although in 3 transplants the reductions were moderate and not statistically significant. The distribution and morphology of NADPH-d neurons within most grafts was comparable to that of NADPH-d neurons in normal host cortex. At the margin of the 2 transplants with no NADPH-d neuronal perikarya, NADPH-d fibers crossed from host to transplant as far as a millimeter into the transplant, and on rare occasions, the host neurons that gave rise to these fibers were identified. This suggests that host-transplant interactions are possible. One transplant had an abnormally large number of NADPH-d-positive neurons and fibers, possibly due to selective survival of these neurons. The data reported here for NADPH-d in cortical transplants may also apply to neuropeptide Y (NPY), since nearly all neocortical NPY neurons also contain NADPH-d.

This article has been cited by other articles:

				B. Mattsson, J. C. Sorensen, J. Zimmer, and B. B. Johansson Neural Grafting to Experimental Neocortical Infarcts Improves Behavioral Outcome and Reduces Thalamic Atrophy in Rats Housed in Enriched but Not in Standard Environments Stroke, June 1, 1997; 28(6): 1225 - 1232. [Abstract] [Full Text]

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