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Journal of Neuroscience, Vol 7, 3215-3229, Copyright © 1987 by Society for Neuroscience
Determinants of multisensory integration in superior colliculus neurons. I. Temporal factors
MA Meredith, JW Nemitz and BE Stein
Department of Anatomy, Virginia Commonwealth University, Richmond 23298.
One of the most impressive features of the central nervous system is its
ability to process information from a variety of stimuli to produce an
integrated, comprehensive representation of the external world. In the
present study, the temporal disparity among combinations of different
sensory stimuli was shown to be a critical factor influencing the
integration of multisensory stimuli by superior colliculus neurons. Several
temporal principles that govern multisensory integration were revealed: (1)
maximal levels of response enhancement were generated by overlapping the
peak discharge periods evoked by each modality; (2) the magnitude of this
enhancement decayed monotonically to zero as the peak discharge periods
became progressively more temporally disparate; (3) with further increases
in temporal disparity, the same stimulus combinations that previously
produced enhancement could often produce depression; and (4) these kinds of
interactions could frequently be predicted from the discharge trains
initiated by each stimulus alone. Since multisensory superior colliculus
neurons project to premotor areas of the brain stem and spinal cord that
control the orientation of the receptor organs (eyes, pinnae, head), they
are believed to influence attentive and orientation behaviors. Therefore,
it is likely that the temporal relationships of different environmental
stimuli that control the activity of these neurons are also a powerful
determinant of superior colliculus-mediated attentive and orientation
behaviors.
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